FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RanBPMCB-6232-3
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General Information
Symbol
Dmel\RanBPMCB-6232-3
Species
D. melanogaster
Name
FlyBase ID
FBal0225260
Feature type
allele
Associated gene
Dmel\RanBPM
Associated Insertion(s)
P{RS3}RanBPMCB-6232-3
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Dansereau and Lasko, 2008)
Mutagen
P-element activity
(Dansereau and Lasko, 2008)
Progenitor genotype
Associated Insertion(s)
P{RS3}RanBPMCB-6232-3
Cytology
Description

P{RS3}RanBPMCB-6232-3 is inserted into the first intron of RanBPM.

(Dansereau and Lasko, 2008)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous RanBPMCB-6232-3 females are fertile, and the majority of their egg chambers develop normally, each individually surrounded by a monolayer of follicle cells. However, in approximately 19% of midstage RanBPMCB-6232-3 egg chambers, clear mislocalization of the oocyte away from the posterior is found.

      (Dansereau and Lasko, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      RanBPMCB-6232-3/RanBPMΔ has egg chamber phenotype, enhanceable by shg[+]/shg2

      (Dansereau and Lasko, 2008)

      RanBPMCB-6232-3/RanBPMΔ has ovary phenotype, enhanceable by shg[+]/shg2

      (Dansereau and Lasko, 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduction in viability of RanBPMΔ/RanBPMCB-6232-3 mutants is dominantly enhanced in a shg2 heterozygous background. Ovaries of RanBPMCB-6232-3 shg2/RanBPMΔ survivors exhibit defects not seen in either RanBPMCB-6232-3/RanBPMΔ or shg2 heterozygotes alone, such as frequent follicle cell multilayering at the poles of egg chambers, severe egg chamber fusion, and loss of epithelial integrity so that many germline cells are no longer surrounded by a somatic cell layer.

      (Dansereau and Lasko, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      RanBPMf06647

      (Dansereau and Lasko, 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The following alleles can be ordered into an allelic series based on their relative strength at 25[o]C: RanBPMΔ > RanBPMf06647 > RanBPMΔN > RanBPMCB-6232-3.

      (Dansereau and Lasko, 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG42236CB-6232-3
      RanBPMCB-6232-3
      RanBPMCB
      (Dansereau and Lasko, 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)