FB2026_02 , released June 18, 2026
Allele: Dmel\Sirt1NP1145
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General Information
Symbol
Dmel\Sirt1NP1145
Species
D. melanogaster
Name
FlyBase ID
FBal0229276
Feature type
allele
Associated gene
Dmel\Sirt1
Associated Insertion(s)
P{GawB}Sirt1NP1145
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}Sirt1NP1145
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Sirt1NP1145/Sirt1NP1145 flies show strongly reduced conditioned odor preference associated with ethanol intoxication, but no defects in olfactory acuity.

        (Engel et al., 2016)

        At 60% ethanol vapor dose, Sir2NP1145 flies show reduced sedation sensitivity, reduced sedation tolerance, and almost no increase in locomotor activity upon repeated ethanol exposure compared to controls. At 73% ethanol vapor dose, Sir2NP1145 flies retain the latter phenotype, but exhibit normal sedation sensitivity and sedation tolerance.

        Sir22A-7-11/Sir2NP1145 flies show almost no increase in locomotor activity upon repeated ethanol exposure compared to controls.

        (Kong et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        NP1145
        (Kong et al., 2010)
        Sir2NP1145
        (Engel et al., 2016)
        Sirt1NP1145
        Name Synonyms
        Secondary FlyBase IDs
          References (3)