FlyBase Allele Report: Dmel\Ero1L[23T]

General Information

Symbol

Dmel\Ero1L^23T

Species

D. melanogaster

Name

FlyBase ID

FBal0230251

Feature type

allele

Associated gene

Dmel\Ero1L

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: W11term.

(Tien et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:4,170,683..4,170,683 [+]

Nucleotide change:

G4170683A

Amino acid change:

W11term | Ero1L-PB

Reported amino acid change:

W11term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation

(exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base

on reported amino acid change.

(Tien et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult head bristle

(Tien et al., 2008)

dorsal head epidermis

(Tien et al., 2008)

egg chamber

(Tien et al., 2008)

follicle cell

(Tien et al., 2008)

macrochaeta & thorax

(Tien et al., 2008)

wing vein

(Tien et al., 2008)

Detailed Description

Statement

Reference

Ero1L^23T homozygous mutant clones exhibit a bristle-tufting phenotype on the head epidermis and thorax, in addition to notching of the wing margin and thickening of the wing veins.

Clones of Ero1L^23T in follicle cells result in the formation of giant compound egg chambers.

(Tien et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Ero1L^23T has dorsal head epidermis phenotype, non-suppressible by Hsap\ERO1A^C394A.UAS/Scer\GAL4^αTub84B.PL

(Tien et al., 2008)

Ero1L^23T has adult head bristle phenotype, non-suppressible by Hsap\ERO1A^C394A.UAS/Scer\GAL4^αTub84B.PL

(Tien et al., 2008)

Ero1L^23T has dorsal head epidermis phenotype, non-suppressible by Hsap\ERO1A^UAS.cTa/Scer\GAL4^αTub84B.PL

(Tien et al., 2008)

Ero1L^23T has adult head bristle phenotype, non-suppressible by Hsap\ERO1A^UAS.cTa/Scer\GAL4^αTub84B.PL

(Tien et al., 2008)

Suppressor of

Statement

Reference

Ero1L[+]/Ero1L^23T is a suppressor of wing vein L4 phenotype of N^Ax-E2

(Tien et al., 2008)

Ero1L[+]/Ero1L^23T is a suppressor of wing vein L5 phenotype of N^Ax-E2

(Tien et al., 2008)

NOT Suppressor of

Statement

Reference

Ero1L[+]/Ero1L^23T is a non-suppressor of wing vein phenotype of Egfr^E1

(Tien et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

A Ero1L^23T heterozygous background does not affect the ectopic wing vein formation phenotype found in Egfr^E1 homozygous mutants.

(Tien et al., 2008)

Xenogenetic Interactions

Statement

Reference

Overexpression of Hsap\Ero1Lβ^{C394A.Lα.Scer\UAS} under the control of Scer\GAL4^αTub84B.PL fails to suppress the tufting phenotype observed in Ero1L^23T mutants.

Overexpression of Hsap\Ero1Lβ^Lα.Scer\UAS under the control of Scer\GAL4^αTub84B.PL supresses the tufting phenotype observed in Ero1L^23T mutants.

(Tien et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

23T

(Tien et al., 2008)

Ero1-like^23T

(Sekine et al., 2013)

Ero1L^23T

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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