FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cdk5α+t5.5
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General Information
Symbol
Dmel\Cdk5α+t5.5
Species
D. melanogaster
Name
FlyBase ID
FBal0230268
Feature type
allele
Associated gene
Dmel\Cdk5α
Associated Insertion(s)
Carried in Construct
P{p35+}
Also Known As
P<up>w+,Tn Cdk5α</up>
Key Links
Transgenic product class
genomic_DNA
(Connell-Crowley et al., 2007)
wild_type
(Connell-Crowley et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Connell-Crowley et al., 2007)
wild_type
(Connell-Crowley et al., 2007)
Mutagen
in vitro construct
(Connell-Crowley et al., 2007)
Progenitor genotype
Carried in construct
P{p35+}
Cytology
Description

Cdk5α+t5.5 is a genomic rescue construct incorporating a 5.5 kb SalI-XbaI restriction fragment spanning the Cdk5α locus in addition to covering CG5385 and part of CG5384.

(Connell-Crowley et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
Cdk5α
Encoded product / tool
Cdk5α
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing four copies of Cdk5α+t5.5 at young age exhibit a similar number of Mushroom Body (MB) neurons while at old age they exhibit a significant decrease in the number of MB neurons compared to controls.

      Adults expressing four copies of Cdk5α+t5.5 are more susceptible to oxidative stress (induced by feeding with paraquat or hydrogen peroxide) compared to controls.

      (Spurrier et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Cdk5α+t5.5 rescues Cdk5α20C/Df(2L)p35-C2

      (Spurrier et al., 2018)

      Cdk5α+t5.5 rescues Cdk5α20C

      (Trunova and Giniger, 2012)

      Cdk5α+t5.5 rescues Cdk5α20C

      (Connell-Crowley et al., 2007)
      Comments

      The age-progressive neurodegeneration (particularly in the mushroom body of the central brain) is rescued by combination with Cdk5α+t5.5.

      (Trunova and Giniger, 2012)

      The reduced adult lifespan phenotype of Cdk5α20C flies can be fully rescued by Cdk5α+t5.5.

      The adult-onset progressive loss of motor function phenotype of Cdk5α20C flies can be fully rescued by Cdk5α+t5.5.

      (Connell-Crowley et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cdk5α+t5.5
      Name Synonyms
      Secondary FlyBase IDs
        References (4)