FlyBase Allele Report: Dmel\ZnT86D[KK101698]

General Information

Symbol

Dmel\ZnT86D^KK101698

Species

D. melanogaster

Name

FlyBase ID

FBal0231428

Feature type

allele

Associated gene

Dmel\ZnT86D

Associated Insertion(s)

Carried in Construct

P{KK101698}

Also Known As

dZnT7 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101698}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101698

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Wei et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by Ras85D^V12.UAS

(Wei et al., 2021)

modeled by Raf^UAS.F179, scrib¹

(Wei et al., 2021)

model of carcinoma

is exacerbated by Atg9^HMS01246

(Wei et al., 2021)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Lee et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^ey.PU

(Wei et al., 2021)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PU

(Wei et al., 2021)

eye disc | larval stage, with Scer\GAL4^ey.PU

(Wei et al., 2021)

Detailed Description

Statement

Reference

The expression of ZnT86D^KK101698 under the control of Scer\GAL4^ey.PU leads to morphological aberrations in the third instar larval eye disc and adult eye.

(Wei et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ey.PU, ZnT86D^KK101698 has visible | adult stage phenotype, suppressible by Atg9^HMS01246, Scer\GAL4^ey.PU

(Wei et al., 2021)

Enhancer of

Statement

Reference

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of neoplasia | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of increased mortality during development | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

Suppressor of

Statement

Reference

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor of increased mortality during development | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor of neoplasia | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

NOT Suppressor of

Statement

Reference

ZnT86D^KK101698/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

ZnT86D^KK101698/Scer\GAL4^GMR.long is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Other

Statement

Reference

Raf^UAS.F179, Scer\GAL4^Act.PU, ZnT86D^KK101698, scrib¹ has majority die during larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ey.PU, ZnT86D^KK101698 has eye phenotype, suppressible by Atg9^HMS01246, Scer\GAL4^ey.PU

(Wei et al., 2021)

Scer\GAL4^ey.PU, ZnT86D^KK101698 has eye disc | larval stage phenotype, suppressible by Atg9^HMS01246, Scer\GAL4^ey.PU

(Wei et al., 2021)

Enhancer of

Statement

Reference

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of eye-antennal disc | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of larval brain | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of gonad | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of embryonic/larval fat body | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of embryonic/larval Malpighian tubule | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of eye disc | larval stage phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

ZnT86D^KK101698, Scer\GAL4^Act.PU is an enhancer of autophagosome | larval stage phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

Suppressor of

Statement

Reference

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor | partially of autophagosome | larval stage phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor of eye-antennal disc | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor of gonad | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor of larval brain | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor of larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU is a suppressor | partially of eye disc | larval stage phenotype of Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹

(Wei et al., 2021)

NOT Suppressor of

Statement

Reference

ZnT86D^KK101698/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The morphological and pigmentation defects in the adult eye seen upon expression of Zip71B^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.long do not change upon co-expression of ZnT86D^KK101698 RNAi.

(Dechen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

ZnT86D^KK101698/Scer\GAL4^GMR.long rescues ZnT86D^UAS.EGFP

(Dechen et al., 2015)

ZnT86D^KK101698/Scer\GAL4^GMR.long rescues ZnT86D^UAS.cDa

(Dechen et al., 2015)

Comments

The eye phenotype (flat shape, partial loss of pigmentation) observed upon expression of ZnT86D^Scer\UAS.cDa under the control of the Scer\GAL4^GMR.long driver can be fully restored by co-expression of ZnT86D^KK101698 RNAi.

The eye phenotype (flat shape, partial loss of pigmentation) observed upon expression of ZnT86D^{Scer\UAS.T:Avic\GFP-EGFP} under the control of the Scer\GAL4^GMR.long driver can be fully restored by co-expression of ZnT86D^KK101698 RNAi.

(Dechen et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107388

P{KK101698}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG6672^KK101698

ZnT86D^KK101698

dZnT86D^RNAi

(Dechen et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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