FlyBase Allele Report: Dmel\Hmgcr[KK101807]

General Information

Symbol

Dmel\Hmgcr^KK101807

Species

D. melanogaster

Name

FlyBase ID

FBal0231489

Feature type

allele

Associated gene

Dmel\Hmgcr

Associated Insertion(s)

Carried in Construct

P{KK101807}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101807}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101807

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Knockdown of Hmgcr^KK101807 driven by Scer\GAL4^jhamt.PW or Scer\GAL4^Aug21 leads to lethality during embryonic, larval and pupal stages.

(Wen et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hmgcr^KK101807, Scer\GAL4^jhamt.PW has partially lethal - majority die phenotype, enhanceable by jhamt²/jhamt²

(Wen et al., 2015)

Hmgcr^KK101807, Scer\GAL4^jhamt.PW has some die during P-stage phenotype, enhanceable by jhamt²/jhamt²

(Wen et al., 2015)

Hmgcr^KK101807, Scer\GAL4^Aug21 has partially lethal - majority die phenotype, enhanceable by jhamt²/jhamt²

(Wen et al., 2015)

Hmgcr^KK101807, Scer\GAL4^Aug21 has some die during P-stage phenotype, enhanceable by jhamt²/jhamt²

(Wen et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^Aug21/Hmgcr^KK101807 is a suppressor | partially of abnormal courtship behavior phenotype of Ecol\lexA^VP16.Ilp2.PL, wake^RNAi.lexAop

(Chen et al., 2022)

Scer\GAL4^jhamt.PU/Hmgcr^KK101807 is a suppressor | partially of abnormal courtship behavior phenotype of Ecol\lexA^VP16.Ilp2.PL, wake^RNAi.lexAop

(Chen et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

jhamt²/jhamt² enhances lethality (especially during the pupal stage) in flies with Hmgcr^KK101807 driven by Scer\GAL4^Aug21 or Scer\GAL4^jhamt.PW.

(Wen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108617

P{KK101807}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hmgcr^KK101807

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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