FlyBase Allele Report: Dmel\jhamt[2]

General Information

Symbol

Dmel\jhamt²

Species

D. melanogaster

Name

FlyBase ID

FBal0318360

Feature type

allele

Associated gene

Dmel\jhamt

Associated Insertion(s)

TI{TI}jhamt²

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Wen et al., 2015)

Mutagen

ends-out gene targeting

(Wen et al., 2015)

FLPase

(Wen et al., 2015)

I-SceI

(Wen et al., 2015)

Progenitor genotype

Associated Insertion(s)

TI{TI}jhamt²

Cytology

Description

The entire jhamt open reading frame has been replaced by a loxP cassette which contains a w^+mW.hs marker.

(Wen et al., 2015)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ovary

(Jia et al., 2024, Wen et al., 2015)

Detailed Description

Statement

Reference

Around 10% of jhamt²/jhamt² larvae die during the larval stage, and initiation of wandering in larvae is delayed. Fecundity of jhamt²/jhamt² females is largely decreased and ovary size is significantly reduced.

Topical application of methoprene partially restores female fecundity and ovary growth.

(Wen et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

jhamt² has decreased fecundity | female phenotype, non-enhanceable by CG10527¹⁸⁷

(Wen et al., 2015)

Enhancer of

Statement

Reference

jhamt²/jhamt² is an enhancer of partially lethal - majority die phenotype of Hmgcr^KK101807, Scer\GAL4^jhamt.PW

(Wen et al., 2015)

jhamt²/jhamt² is an enhancer of some die during P-stage phenotype of Hmgcr^KK101807, Scer\GAL4^jhamt.PW

(Wen et al., 2015)

jhamt²/jhamt² is an enhancer of partially lethal - majority die phenotype of Hmgcr^KK101807, Scer\GAL4^Aug21

(Wen et al., 2015)

jhamt²/jhamt² is an enhancer of some die during P-stage phenotype of Hmgcr^KK101807, Scer\GAL4^Aug21

(Wen et al., 2015)

Other

Statement

Reference

Cyp6g2^KO, jhamt² has abnormal developmental rate phenotype

(Jia et al., 2024)

Cyp6g2^KO, jhamt² has decreased body size | P-stage phenotype

(Jia et al., 2024)

Cyp6g2^KO, jhamt² has lethal - all die before end of P-stage phenotype

(Jia et al., 2024)

Cyp6g2^KO, jhamt² has majority die during P-stage phenotype

(Jia et al., 2024)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

jhamt² has ovary phenotype, non-enhanceable by CG10527¹⁸⁷

(Wen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

CG10527¹⁸⁷ does not enhance ovary size or fecundity phenotypes in jhamt²/jhamt² flies.

jhamt²/jhamt² enhances lethality (especially during the pupal stage) in flies with Hmgcr^KK101807 driven by Scer\GAL4^Aug21 or Scer\GAL4^jhamt.PW.

(Wen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

jhamt² is rescued by jhamt^UAS.cBa/Scer\GAL4^Aug21

(Wen et al., 2015)

jhamt² is rescued by jhamt^UAS.cBa/Scer\GAL4^jhamt.PW

(Wen et al., 2015)

Comments

jhamt^Scer\UAS.cBa driven by Scer\GAL4^Aug21 or Scer\GAL4^jhamt.PW rescues fecundity and ovary growth in jhamt²/jhamt² flies.

(Wen et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

jhamt²

(Jia et al., 2024, Wu et al., 2021, Wen et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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