FlyBase Allele Report: Dmel\Pdha1[KK101856]

General Information

Symbol

Dmel\Pdha1^KK101856

Species

D. melanogaster

Name

FlyBase ID

FBal0231523

Feature type

allele

Associated gene

Dmel\Pdha1

Associated Insertion(s)

Carried in Construct

P{KK101856}

Also Known As

Pdha RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101856}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101856

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal wound healing | larval stage, with Scer\GAL4^repo

(Li et al., 2020)

Phenotype Manifest In

larval multidendritic class IV neuron, with Scer\GAL4^repo

(Li et al., 2020)

Detailed Description

Statement

Reference

Number of midgut cells per MARCM clone expressing Pdha^KK101856 under the control of Scer\GAL4^Tub.PU is similar to control adults under calorie-restricted condition.

(Mattila et al., 2018)

Expression of l(1)G0334^KK101856 under the control of Scer\GAL4^sal.BO (in combination with a Dicer-2 transgene to enhance RNAi efficiency) does not result in larval lethality at the L2/L3 transition.

(Wicker-Thomas et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pdha1^KK101856/Scer\GAL4^ppk.PU is a suppressor of abnormal wound healing | larval stage phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Pdha1^KK101856/Scer\GAL4^ppk.PU is a suppressor of larval multidendritic class IV neuron phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

Pdha1^KK101856/Scer\GAL4^elav.PLu is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Pdha1^KK101856/Scer\GAL4^elav.PLu is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Pdha1^KK101856, Scer\GAL4^nSyb.PS is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of SREBP^UAS.cKa, Scer\GAL4^nSyb.PS

(Liu et al., 2017)

Pdha1^KK101856, Scer\GAL4^nSyb.PS is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of SREBP^UAS.cKa, Scer\GAL4^nSyb.PS

(Liu et al., 2017)

Pdha1^KK101856, Scer\GAL4^nSyb.PS is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of Scer\GAL4^nSyb.PS, bsk^UAS.cBa

(Liu et al., 2017)

Pdha1^KK101856, Scer\GAL4^nSyb.PS is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of Scer\GAL4^nSyb.PS, bsk^UAS.cBa

(Liu et al., 2017)

NOT Suppressor of

Statement

Reference

Pdha1^KK101856/Scer\GAL4^54C is a non-suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Pdha1^KK101856/Scer\GAL4^54C is a non-suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is not suppressed by Scer\GAL4^54C-driven (glial) expression of Pdha^KK101856 while expression under the control of the neuronal Scer\GAL4^elav.PLu driver efficiently rescues the phenotype.

The accumulation of lipid droplets in the retinal glia of adult flies expressing either SREBP^UAS.cKa or bsk^Scer\UAS.cBa under the control of Scer\GAL4^nSyb.PS is significantly suppressed by co-expression of Pdha^KK101856.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107209

P{KK101856}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pdha1^KK101856

Pdha^KK101856

l(1)G0334^KK101856

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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