FlyBase Allele Report: Dmel\Pi3K92E[KK102291]

General Information

Symbol

Dmel\Pi3K92E^KK102291

Species

D. melanogaster

Name

FlyBase ID

FBal0231711

Feature type

allele

Associated gene

Dmel\Pi3K92E

Associated Insertion(s)

Carried in Construct

P{KK102291}

Also Known As

PI3K^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102291}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102291

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of glucose metabolism disease

CEA

(Mascolo et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Delta^UAS.cDa, ct^RNAi.cGa.UAS

(Zhai et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | adult stage, with Scer\GAL4^ppl.PP

(Mascolo et al., 2022)

decreased body weight | adult stage, with Scer\GAL4^ppl.PP

(Mascolo et al., 2022)

decreased size | adult stage, with Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

visible | adult stage, with Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Phenotype Manifest In

chromosome | larval stage, with Scer\GAL4^Act.PU

(Mascolo et al., 2022)

chromosome | larval stage, with Scer\GAL4^ppl.PP

(Mascolo et al., 2022)

larval brain | larval stage, with Scer\GAL4^Act.PU

(Mascolo et al., 2022)

larval neuroblast, with Scer\GAL4^Act.PU

(Mascolo et al., 2022)

larval neuroblast, with Scer\GAL4^ppl.PP

(Mascolo et al., 2022)

wing, with Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Detailed Description

Statement

Reference

Expression of Pi3K92E^KK102291 under the control of Scer\GAL4^salm.EPv leads to a reduction in the wing size.

(Vega-Cuesta et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pi3K92E^KK102291, Scer\GAL4^salm.EPv has visible | adult stage phenotype, enhanceable by Ras85D^{V12.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Pi3K92E^KK102291, Scer\GAL4^salm.EPv has decreased size | adult stage phenotype, enhanceable by Ras85D^{V12.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

NOT suppressed by

Statement

Reference

Pi3K92E^KK102291, Scer\GAL4^salm.EPv has visible | adult stage phenotype, non-suppressible by Ras64B^{V14.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Pi3K92E^KK102291, Scer\GAL4^salm.EPv has decreased size | adult stage phenotype, non-suppressible by Ras64B^{V14.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Suppressor of

Statement

Reference

Pi3K92E^KK102291, Scer\GAL4^NP0677 is a suppressor of increased cell number phenotype of Scer\GAL4^NP0677, mir-305^{sponge.UAS.DsRed(Unk)}

(Foronda et al., 2014)

Pi3K92E^KK102291, Scer\GAL4^esg.PU is a suppressor of increased cell number phenotype of Scer\GAL4^esg.PU, mir-305^{sponge.UAS.DsRed(Unk)}

(Foronda et al., 2014)

Pi3K92E^KK102291, Scer\GAL4^ey.PU is a suppressor | partially of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PU, ct^RNAi.cGa.UAS

(Zhai et al., 2012)

Other

Statement

Reference

Delta^UAS.cDa, Pi3K92E^KK102291, Scer\GAL4^ey.PU has visible phenotype

(Zhai et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pi3K92E^KK102291, Scer\GAL4^salm.EPv has wing phenotype, enhanceable by Ras85D^{V12.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

NOT suppressed by

Statement

Reference

Pi3K92E^KK102291, Scer\GAL4^salm.EPv has wing phenotype, non-suppressible by Ras64B^{V14.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Suppressor of

Statement

Reference

Pi3K92E^KK102291, Scer\GAL4^esg.PU is a suppressor of intestinal stem cell | adult stage phenotype of Scer\GAL4^esg.PU, mir-305^{sponge.UAS.DsRed(Unk)}

(Foronda et al., 2014)

Pi3K92E^KK102291, Scer\GAL4^esg.PU is a suppressor of enteroblast | adult stage phenotype of Scer\GAL4^esg.PU, mir-305^{sponge.UAS.DsRed(Unk)}

(Foronda et al., 2014)

Pi3K92E^KK102291, Scer\GAL4^NP0677 is a suppressor of intestinal stem cell | adult stage phenotype of Scer\GAL4^NP0677, mir-305^{sponge.UAS.DsRed(Unk)}

(Foronda et al., 2014)

Pi3K92E^KK102291, Scer\GAL4^NP0677 is a suppressor of enteroblast | adult stage phenotype of Scer\GAL4^NP0677, mir-305^{sponge.UAS.DsRed(Unk)}

(Foronda et al., 2014)

Pi3K92E^KK102291, Scer\GAL4^ey.PU is a suppressor | partially of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PU, ct^RNAi.cGa.UAS

(Zhai et al., 2012)

Other

Statement

Reference

Delta^UAS.cDa, Pi3K92E^KK102291, Scer\GAL4^ey.PU has eye phenotype

(Zhai et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Pi3K92E^KK102291 partially suppresses the tumorous eye growth seen in flies co-expressing ct^{dsRNA.cGa.Scer\UAS} and Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PU.

Flies co-expressing Pi3K92E^KK102291 and Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PU have small eyes.

(Zhai et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107390

P{KK102291}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PI3K92E^RNAi

(Mascolo et al., 2022)

PI3K^RNAi

(Mascolo et al., 2022)

Pi3K92E^KK102291

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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