FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nhe2KK102518
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General Information
Symbol
Dmel\Nhe2KK102518
Species
D. melanogaster
Name
FlyBase ID
FBal0231837
Feature type
allele
Associated gene
Dmel\Nhe2
Associated Insertion(s)
Carried in Construct
P{KK102518}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK102518}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK102518
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  nephrolithiasis
      CEA
      (Ghimire et al., 2019)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing Nhe2KK102518 under the control of Scer\GAL4ClC-a.PU present numerous birefringent stones in the Malpighian tubules's lumen.

      (Ghimire et al., 2019)

      The expression of Nhe2KK102518 under the control of Scer\GAL4109-30 leads to frequent germarium defects including cyst encapsulation defects and/or disorganized follicular epithelium, loss of germline stem cells, and signs of stalk cells mis-differentiation (i.e. ectopic expression of Eya), as compared to controls. This expression leads to a significant decrease in intracellular pH in pre-follicle and follicle cells within the germarium, as compared to controls.

      (Ulmschneider et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DNhe2KK102518
      (Ulmschneider et al., 2016)
      Nhe2KK102518
      Name Synonyms
      Secondary FlyBase IDs
        References (4)