FB2026_02 , released June 18, 2026
Allele: Dmel\mnbKK102642
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General Information
Symbol
Dmel\mnbKK102642
Species
D. melanogaster
Name
FlyBase ID
FBal0231912
Feature type
allele
Associated gene
Dmel\mnb
Associated Insertion(s)
Carried in Construct
P{KK102642}
Also Known As
UAS-mnb RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK102642}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK102642
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Vissers-Bodmer syndrome
      modeled by Not1GD4070
      (Vissers et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Presynaptic expression of mnbKK102642 under the control of Scer\GAL4elav-C155 causes synaptic retractions in less than 20% of synapses.

      (Bulat et al., 2014)

      The tarsal segments of legs from flies expressing mnbKK102642 under the control of Scer\GAL4hh.PU are 7% smaller than in controls.

      Expression of mnbKK102642 under the control of Scer\GAL4rn.PU results in a significant reduction in wing size.

      (Degoutin et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4rn.PU, mnbKK102642 has abnormal size phenotype, non-suppressible by Scer\GAL4rn.PU/wapUAS.cDa

      (Degoutin et al., 2013)
      Suppressor of
      Statement
      Reference

      mnbKK102642/Scer\GAL4rn.PU is a suppressor of abnormal size phenotype of Scer\GAL4rn.PU, wapUAS.cDa

      (Degoutin et al., 2013)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4rn.PU, mnbKK102642 has wing phenotype, non-suppressible by Scer\GAL4rn.PU/wapUAS.cDa

      (Degoutin et al., 2013)
      Suppressor of
      Statement
      Reference

      mnbKK102642/Scer\GAL4rn.PU is a suppressor of wing phenotype of Scer\GAL4rn.PU, wapUAS.cDa

      (Degoutin et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of mnbKK102642 suppresses the wing overgrowth seen when wapScer\UAS.cDa is expressed under the control of Scer\GAL4rn.PU. The resulting wings are undergrown, and are similar in size to wings expressing mnbKK102642 alone.

      (Degoutin et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DYRK1aRNAi
      (Vissers et al., 2020)
      mnbKK102642
      Name Synonyms
      Secondary FlyBase IDs
        References (8)