FlyBase Allele Report: Dmel\Pss[KK105709]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Pss^KK105709

General Information

Symbol

Dmel\Pss^KK105709

Species

D. melanogaster

Name

FlyBase ID

FBal0233733

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell size | third instar larval stage, with Scer\GAL4^AB1

(Yang et al., 2019)

decreased cell size | third instar larval stage, with Scer\GAL4^ppl.PP

(Yang et al., 2019)

decreased size | third instar larval stage, with Scer\GAL4^AB1

(Yang et al., 2019)

decreased size | third instar larval stage, with Scer\GAL4^ppl.PP

(Yang et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Pss^KK105709 under the control of Scer\GAL4^ppl.PP or Scer\GAL4^AB1 leads to small third instar larval salivary glands, due to small cells, with ectopic lipid accumulation; mitochondrial morphology is grossly aberrant, with disorganized, often bent, looped and branched cristae; the mitochondria crista junction width is increased and the electron density is higher at the junction sites.

(Yang et al., 2019)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pss^KK105709, Scer\GAL4^ppl.PP has decreased cell size | third instar larval stage phenotype, enhanceable by Pisd^EY03559, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Suppressed by

Statement

Reference

Pss^KK105709, Scer\GAL4^ppl.PP has decreased cell size | third instar larval stage phenotype, suppressible by Akt^{UAS.Tag:Myr(Unk)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has decreased cell size | third instar larval stage phenotype, suppressible by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Suppressor of

Statement

Reference

Pss^KK105709, Scer\GAL4^ppl.PP is a suppressor of increased cell size | third instar larval stage phenotype of Akt^{UAS.Tag:Myr(Unk)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP is a suppressor of increased cell size | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pss^KK105709, Scer\GAL4^ppl.PP has embryonic/larval salivary gland | third instar larval stage phenotype, enhanceable by Pisd^EY03559, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has mitochondrial crista | third instar larval stage phenotype, enhanceable by Pisd^EY03559, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has mitochondrion | third instar larval stage phenotype, enhanceable by Pisd^EY03559, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has embryonic/larval salivary gland | third instar larval stage phenotype, enhanceable by Cds^EY08412, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has mitochondrial crista | third instar larval stage phenotype, enhanceable by Cds^EY08412, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Suppressed by

Statement

Reference

Pss^KK105709, Scer\GAL4^ppl.PP has embryonic/larval salivary gland | third instar larval stage phenotype, suppressible by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has embryonic/larval salivary gland | third instar larval stage phenotype, suppressible by Cds^EY08412, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has embryonic/larval salivary gland | third instar larval stage phenotype, suppressible by Lpin^GD14004, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has lipid droplet | increased number phenotype, suppressible by Cds^EY08412, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has lipid droplet | increased number phenotype, suppressible by Lpin^GD14004, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has embryonic/larval salivary gland | third instar larval stage phenotype, suppressible by Akt^{UAS.Tag:Myr(Unk)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

NOT suppressed by

Statement

Reference

Pss^KK105709, Scer\GAL4^ppl.PP has lipid droplet | increased number phenotype, non-suppressible by Akt^{UAS.Tag:Myr(Unk)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has lipid droplet | increased number phenotype, non-suppressible by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has embryonic/larval salivary gland | third instar larval stage phenotype, non-suppressible by Pisd^EY03559, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has mitochondrion phenotype, non-suppressible by Cds^EY08412, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP has lipid droplet | increased number phenotype, non-suppressible by Pisd^EY03559, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Suppressor of

Statement

Reference

Pss^KK105709, Scer\GAL4^ppl.PP is a suppressor of embryonic/larval salivary gland | third instar larval stage phenotype of Akt^{UAS.Tag:Myr(Unk)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Pss^KK105709, Scer\GAL4^ppl.PP is a suppressor of embryonic/larval salivary gland | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v105470

P{KK105709}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG4825^KK105709

Pss^KK105709

l(3)77CDf^KK105709

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections