FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AktUAS.Tag:Myr(Unk)
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General Information
Symbol
Dmel\AktUAS.Tag:Myr(Unk)
Species
D. melanogaster
Name
FlyBase ID
FBal0285731
Feature type
allele
Associated gene
Dmel\Akt
Associated Insertion(s)
Carried in Construct
P{UAS-myr-Akt.V}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Diangelo et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-myr-Akt.V}
Cytology
Description

FlyBase curator comment: a 'UAS-myr-Akt1' stock submitted to the Bloomington Drosophila Stock Center by S. Birnbaum was subsequently found to contain an N-terminal deletion in the coding sequence, removing 75% of the PH domain (stock 80935, see FBrf0241238 , personal communication to FlyBase). It is not known whether the 'myrAkt' fly line used in FBrf0238295 corresponds to this deleted construct or whether it contains Akt1 full-length coding sequence.

(Roth et al., 2018)

UAS regulatory sequences drive expression of an active form of Akt1 (protein is tagged with a myristoylation signal). FlyBase curator comment: a 'UAS-myr-Akt1' stock submitted to the Bloomington Drosophila Stock Center by S. Birnbaum was subsequently found to contain an N-terminal deletion in the coding sequence, removing 75% of the PH domain (stock 80935, see FBrf0241238 , personal communication to FlyBase). It is not known whether the 'myrAkt' fly line described in FBrf0211161 corresponds to this deleted construct or whether it contains Akt1 full-length coding sequence.

(Diangelo et al., 2009)

FlyBase curator comment: the UAS-Dakt[myr] fly line used in FBrf0194781 is referenced to FBrf0123227, where a UAS-Dakt[myr] plasmid is transfected into cells. A 'UAS-myr-Akt1' stock submitted to the Bloomington Drosophila Stock Center by S. Birnbaum (an author on FBrf0194781 and FBrf0123227) was subsequently found to contain an N-terminal deletion in the coding sequence, removing 75% of the PH domain (stock 80935, see FBrf0241238 , personal communication to FlyBase). It is not known whether the 'UAS-Dakt[myr]' fly line used in FBrf0194781 corresponds to this deleted construct or whether it contains Akt1 full-length coding sequence.

(Liu and Lehmann, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Akt
Tagged with
Tag:Myr(Unk)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  glucose metabolism disease
      modeled by Tl10b.UAS.cUa
      (Roth et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Posterior dorsocentral bristle neurons expressing Akt1HM04007 under the control of Scer\GAL4pnr-MD237 show a severely increased terminal arbor territory and significantly more synapses (Syt1 puncta) on the contralateral collateral branch, as compared to controls.

      (Urwyler et al., 2019)

      The expression of AktUAS.Tag:Myr(Unk) under the control of Scer\GAL4ppl.PP leads to third instar larval salivary glands exhibiting large cells.

      (Yang et al., 2019)

      Clonal expression of Akt1UAS.Tag:Myr(Unk) under the control of Scer\GAL4Act5C.PP in the larval fat body induces larger cells and larger nuclei, as compared to neighboring control cells.

      (Roth et al., 2018)

      100% of pupae expressing Akt1Scer\UAS.T:Uuuu\Myr5 under the control of Scer\GAL4hs.PB (using a 30 minute heat shock at 9 hours after puparium formation) still possess intact salivary glands at 20 hours after puparium formation (this is approximately 6 hours after the glands are normally destroyed in wild-type animals).

      (Liu and Lehmann, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Larval fat body clones co-expressing Tl10b.UAS.cUa and Akt1UAS.Tag:Myr(Unk) under the control of Scer\GAL4Act5C.PP exhibit the same cell and nucleus size increases as observed upon Akt1UAS.Tag:Myr(Unk) single expression (although the increased nucleus size is partially suppressed), instead of the cell and nucleus size decreases observed upon Tl10b.UAS.cUa single expression.

      (Roth et al., 2018)

      Co-expression of Akt1Scer\UAS.T:Uuuu\Myr5 rescues the reduced size of larvae and adult escapers expressing Tl10b.Scer\UAS.cUa under the control of Scer\GAL4r4.

      (Diangelo et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Akt1Scer\UAS.T:Uuuu\Myr-Unk
      Akt1Scer\UAS.T:Uuuu\Myr5
      Akt1UAS.Tag:Myr(Unk)
      AktUAS.Tag:Myr(Unk)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)