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Verdu, J., Buratovich, M.A., Wilder, E.L., Birnbaum, M.J. (1999). Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.  Nat. Cell Biol. 1(8): 500--506.
FlyBase ID
FBrf0123227
Publication Type
Research paper
Abstract

Organismal size is determined by a tightly regulated mechanism that coordinates cell growth, cell proliferation and cell death. The Drosophila insulin receptor/Chico/Dp110 pathway regulates cell and organismal size. Here we show that genetic manipulation of the phosphoinositide-3-OH-kinase-dependent serine/threonine protein kinase Akt (protein kinase B) during development of the Drosophila imaginal disc affects cell and organ size in an autonomous manner. Ectopic expression of Akt does not affect cell-fate determination, apoptosis or proliferation rates in imaginal discs. Thus, Akt appears to stimulate intracellular pathways that specifically regulate cell and compartment size independently of cell proliferation in vivo.

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Review

From small flies come big discoveries about size control.
Edgar, 1999, Nat. Cell Biol. 1(8): E191--E193 [FBrf0123004]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Cell Biol.
    Title
    Nature Cell Biology
    Publication Year
    1999-
    ISBN/ISSN
    1465-7392 1476-4679
    Data From Reference