FlyBase Allele Report: Dmel\mth[KK106399]

General Information

Symbol

Dmel\mth^KK106399

Species

D. melanogaster

Name

FlyBase ID

FBal0234226

Feature type

allele

Associated gene

Dmel\mth

Associated Insertion(s)

Carried in Construct

P{KK106399}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK106399}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK106399

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response, with Scer\GAL4^ple.PF

(Shukla et al., 2014)

chemical resistant, with Scer\GAL4^ple.PF

(Shukla et al., 2014)

increased size | adult stage, with Scer\GAL4^nub.PU

(Saad and Hipfner, 2021)

visible | adult stage, with Scer\GAL4^nub.PU

(Saad and Hipfner, 2021)

Phenotype Manifest In

wing, with Scer\GAL4^nub.PU

(Saad and Hipfner, 2021)

wing vein | ectopic, with Scer\GAL4^nub.PU

(Saad and Hipfner, 2021)

Detailed Description

Statement

Reference

Compared to controls, mth^KK106399 Scer\GAL4^ple.PF flies exposed to paraquat (to induce oxidative stress) show less degeneration of dopaminergic neurons compared to controls.

(Shukla et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^ple.PF, mth^KK106399 has chemical resistant phenotype, non-enhanceable by Scer\GAL4^ple.PF/bsk^KK108156

(Shukla et al., 2014)

Scer\GAL4^ple.PF, mth^KK106399 has abnormal oxidative stress response phenotype, non-enhanceable by Scer\GAL4^ple.PF/bsk^KK108156

(Shukla et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^ple.PF, mth^KK106399 has chemical resistant phenotype, non-suppressible by Scer\GAL4^ple.PF/bsk^KK108156

(Shukla et al., 2014)

Scer\GAL4^ple.PF, mth^KK106399 has abnormal oxidative stress response phenotype, non-suppressible by Scer\GAL4^ple.PF/bsk^KK108156

(Shukla et al., 2014)

NOT Enhancer of

Statement

Reference

mth^KK106399, Scer\GAL4^ple.PF is a non-enhancer of chemical resistant phenotype of Diap1^UAS.cHa, Scer\GAL4^ple.PF

(Shukla et al., 2014)

mth^KK106399, Scer\GAL4^ple.PF is a non-enhancer of abnormal oxidative stress response phenotype of Diap1^UAS.cHa, Scer\GAL4^ple.PF

(Shukla et al., 2014)

NOT Suppressor of

Statement

Reference

mth^KK106399, Scer\GAL4^ple.PF is a non-suppressor of chemical resistant phenotype of Diap1^UAS.cHa, Scer\GAL4^ple.PF

(Shukla et al., 2014)

mth^KK106399, Scer\GAL4^ple.PF is a non-suppressor of abnormal oxidative stress response phenotype of Diap1^UAS.cHa, Scer\GAL4^ple.PF

(Shukla et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102303

P{KK106399}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mth^KK106399

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close