FlyBase Allele Report: Dmel\Ntan1[KK107726]

General Information

Symbol

Dmel\Ntan1^KK107726

Species

D. melanogaster

Name

FlyBase ID

FBal0235123

Feature type

allele

Associated gene

Dmel\Ntan1

Associated Insertion(s)

Carried in Construct

P{KK107726}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107726}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107726

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal endomitotic cell cycle | third instar larval stage, with Scer\GAL4^Gli.PU

(Zülbahar et al., 2018)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Gli.PU

(Zülbahar et al., 2018)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Third instar larvae expressing Ntan1^KK107726 under the control of Scer\GAL4^repo.PU exhibit defasciculated axons and glial bulges that accumulate glial nuclei along peripheral nerves, as compared to controls; expression under the control of Scer\GAL4^46F does not result in nerve bulges but induces a small but significant increase in the number of perineurial glial nuclei in the long nerves A6 and A7, as compared to controls; expression under the control of Scer\GAL4^nrv2.PS leads to no obvious axonal defasciculations in the abdominal peripheral nerves or changes in nuclei number of the wrapping glia, as compared to controls.

The expression of Ntan1^KK107726 under the control of Scer\GAL4^Gli.PU leads to bulges in peripheral nerves, associated to a severe increase in subperineurial glial cell nuclei number and to multi-nucleated cells, which is an indication of an increased endomitosis, as compared to controls; subperineurial glial cells in both the central and peripheral nervous systems are more frequently in S-phase than in controls.

(Zülbahar et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ntan1^KK107726, Scer\GAL4^repo.PU has abnormal neuroanatomy | third instar larval stage | third instar larval stage phenotype, suppressible by yki^HMS00041, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

Ntan1^KK107726, Scer\GAL4^repo.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by htl^DN.UAS.cMb, Scer\GAL4^repo.PU