FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\αSnapKK107910
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General Information
Symbol
Dmel\αSnapKK107910
Species
D. melanogaster
Name
FlyBase ID
FBal0235246
Feature type
allele
Associated gene
Dmel\αSnap
Associated Insertion(s)
Carried in Construct
P{KK107910}
Also Known As
UAS-αSNAPRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK107910}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK107910
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of αSnapKK107910 under the control of CtxGlia-SplitGal4 (Hsim\VP16AD.nrv2 and Scer\GAL4DBD.wrapper.932i) leads to an increase in cell death (DCP1 staining) in the VNC, an increase in the number of astrocytes crossing the neuropil-cortex boundary in the VNC, a decrease in the number of cortex glia cells, a globular cortex glia without processes between neurons, a decrease in crawling velocity and a decrease in linear distance travelled from the start to the end of the crawling path in third instar larvae when compared to controls.

      Expression of αSnapKK107910 under the control of Scer\GAL4GMR54H02 leads to a decrease in calcium transients in second instar larval cortex glia when compared to controls.

      (Coutinho-Budd et al., 2017)
      External Data
      Interactions
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SnapKK107910
      αSnapKK107910
      Name Synonyms
      Secondary FlyBase IDs
        References (7)