FlyBase Allele Report: Dmel\shrb[KK108557]

General Information

Symbol

Dmel\shrb^KK108557

Species

D. melanogaster

Name

FlyBase ID

FBal0235648

Feature type

allele

Associated gene

Dmel\shrb

Associated Insertion(s)

Carried in Construct

P{KK108557}

Also Known As

UAS-shrubRNAi, Vps32 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108557}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108557

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal lateral adult muscle precursor cell | third instar larval stage, with Scer\GAL4^{E(spl)m6-BFM.PF}

(Aradhya et al., 2015)

cystic bulge | decreased number, with Scer\GAL4^{VP16.nanos.UTR}

(Chen et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

embryonic/larval plasmatocyte | increased number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

lamellocyte | increased number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

nucleus | increased number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

primary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

secondary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

spermatozoon | absent, with Scer\GAL4^{VP16.nanos.UTR}

(Chen et al., 2021)

tertiary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

testis, with Scer\GAL4^{VP16.nanos.UTR}

(Chen et al., 2021)

waste bag | absent, with Scer\GAL4^{VP16.nanos.UTR}

(Chen et al., 2021)

Detailed Description

Statement

Reference

Expression of shrb^KK108557 under the control of Scer\GAL4^{E(spl)m6-BFM.PF} leads to increased numbers of abdominal lateral adult muscle precursor cells in third instar larvae, as compared to controls.

(Aradhya et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^dome-PG14, shrb^KK108557 has increased cell number | larval stage phenotype, non-suppressible by dx^GLC01607/Scer\GAL4^dome-PG14

(Ray et al., 2024)

Scer\GAL4^dome-PG14, shrb^KK108557 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^dome-PG14/eIF3f1^HMS00940

(Ray et al., 2024)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^dome-PG14, shrb^KK108557 has embryonic/larval crystal cell | increased number | larval stage phenotype, non-suppressible by dx^GLC01607/Scer\GAL4^dome-PG14

(Ray et al., 2024)

Scer\GAL4^dome-PG14, shrb^KK108557 has embryonic/larval crystal cell | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^dome-PG14/eIF3f1^HMS00940

(Ray et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106823

P{KK108557}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

shrb^KK108557

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections