FlyBase Allele Report: Dmel\Octβ2R[KK109808]

General Information

Symbol

Dmel\Octβ2R^KK109808

Species

D. melanogaster

Name

FlyBase ID

FBal0236493

Feature type

allele

Associated gene

Dmel\Octβ2R

Associated Insertion(s)

Carried in Construct

P{KK109808}

Also Known As

UAS-Octβ2r^RNAi, Octβ2R RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109808}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109808

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | adult stage, with Scer\GAL4^GMR26E01

(Yang et al., 2016)

abnormal memory | adult stage, with Scer\GAL4^GMR42D07

(Yang et al., 2016)

abnormal memory | adult stage, with Scer\GAL4^VT037861

(Yang et al., 2016)

abnormal memory | adult stage, with Scer\GAL4^VT050658

(Yang et al., 2016)

abnormal starvation stress response, with Scer\GAL4^futsch-C380

(Koon et al., 2011)

abnormal starvation stress response, with Scer\GAL4^Tdc2.PC

(Koon et al., 2011)

female semi-fertile, with Scer\GAL4^Mef2.PU

(Li et al., 2015)

female semi-sterile, with Scer\GAL4^Tub.PU

(Li et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of VGlut^KK107498 under the control of Scer\GAL4^VT050658, Scer\GAL4^VT037861, Scer\GAL4^GMR42D07 or Scer\GAL4^GMR26E01 significantly reduces 3-hour aversive olfactory anaesthesia-resistant memory, compared to controls.

(Yang et al., 2016)

Females with expression of Octβ2R^KK109808 driven by Scer\GAL4^tub.PU or Scer\GAL4^Mef2.PU (but not Scer\GAL4^nSyb.PU) lay significantly fewer eggs than controls.

(Li et al., 2015)

Expression of Octβ2R^KK109808 in octopaminergic neurons, under the control of Scer\GAL4^Tdc2.PC, results in a significant decrease in the number of type II boutons.

Expression of Octβ2R^KK109808 in both type I and type II motor neurons, under the control of Scer\GAL4^futsch-C380, causes a significant reduction in the number of type II boutons. By contrast, expression in the muscle, under the control of Scer\GAL4^C57, has no effect.

Expression of Octβ2R^GD2954 either in octopaminergic neurons or both type I and type II motor neurons (under the control of Scer\GAL4^Tdc2.PC or Scer\GAL4^futsch-C380) but not in the muscle (under the control of Scer\GAL4^C57), downregulates the locomotor speed response to starvation.

Expression of Octβ2R^GD2954 in both type I and type II motor neurons (under the control of Scer\GAL4^futsch-C380) or in type I but not type II motor neurons (under the control of Scer\GAL4^BG439) results in a significant decrease in the number of type I boutons. By contrast, expression in octopamine neurons alone (under the control of Scer\GAL4^Tdc2.PC) does not result in a significant decrease in the number of type I boutons.

(Koon et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^VT030604/Octβ2R^KK109808 is an enhancer of abnormal memory | adult stage phenotype of rsh¹

(Yang et al., 2016)

NOT Enhancer of

Statement

Reference

Octβ2R^KK109808/Scer\GAL4^VT049246 is a non-enhancer of abnormal memory | adult stage phenotype of rsh¹

(Yang et al., 2016)

NOT Suppressor of

Statement

Reference

Octβ2R^KK109808/Scer\GAL4^VT049246 is a non-suppressor of abnormal memory | adult stage phenotype of rsh¹

(Yang et al., 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of TrpA1^{Ecol\lexAop.cBa} under the control of Ecol\lexA^{Tdc2.T:Hsim\VP16} at 31[o]C contingent with odour presentation does not induce appetitive olfactory memory in hungry flies if the flies are also carrying Scer\GAL4^c061, Scer\GAL80^Mef2.PT and Octβ2R^KK109808 (to knock down Octβ2R expression in the MB-MP1 neurons).

(Burke et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104524

P{KK109808}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Octβ2R^KK109808

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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