FlyBase Allele Report: Dmel\COX7A[KK110870]

General Information

Symbol

Dmel\COX7A^KK110870

Species

D. melanogaster

Name

FlyBase ID

FBal0237082

Feature type

allele

Associated gene

Dmel\COX7A

Associated Insertion(s)

Carried in Construct

P{KK110870}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK110870}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK110870

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cytochrome-c oxidase deficiency disease

CEA

(Kemppainen et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cytochrome-c oxidase deficiency disease

is ameliorated by Zzzz\AOX^Scer\UAS.cFa

(Kemppainen et al., 2014)

is ameliorated by Cint\AOX^UAS.cFa

(Kemppainen et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^ChAT.7.4

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

(Yalgin et al., 2020, Kemppainen et al., 2014)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51B08

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51C07

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51C09

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51G05

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR52A01

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR55A05

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR59E04

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^VGlut1-OK371

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^VT001211

(Yalgin et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^VT001215

(Yalgin et al., 2020)

bang sensitive, with Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

increased cell death | adult stage, with Scer\GAL4^elav-C155

(Yalgin et al., 2020)

lethal - all die during P-stage, with Scer\GAL4^da.PU

(Kemppainen et al., 2014)

short lived | adult stage, with Scer\GAL4^elav-C155

(Yalgin et al., 2020)

Phenotype Manifest In

adult brain, with Scer\GAL4^elav-C155

(Yalgin et al., 2020)

Detailed Description

Statement

Reference

Expression of COX7A^KK110870 driven by Scer\GAL4^elav-C155 (but not when driven by Scer\GAL4^G14) results in significant climbing defects in 14 day old flies and bang sensitivity (significantly increased recovery time at 29[o]C in 7 day old flies).

(Kemppainen et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

COX7A^KK110870, Scer\GAL4^da.PU has lethal - all die during P-stage phenotype, suppressible by Cint\AOX^UAS.cFa, Scer\GAL4^da.PU

(Kemppainen et al., 2014)

COX7A^KK110870, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

COX7A^KK110870, Scer\GAL4^elav-C155 has bang sensitive phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

NOT suppressed by

Statement

Reference

COX7A^KK110870, Scer\GAL4^da.PU has lethal - all die during P-stage phenotype, non-suppressible by Scer\NDI1^UAS.cSa, Scer\GAL4^da.PU

(Kemppainen et al., 2014)

Other

Statement

Reference

COX7A^KK110870, Cint\AOX^UAS.cFa, Scer\GAL4^da.PU has abnormal locomotor behavior | adult stage | progressive phenotype

(Kemppainen et al., 2014)

COX7A^KK110870, Cint\AOX^UAS.cFa, Scer\GAL4^da.PU has bang sensitive | progressive phenotype

(Kemppainen et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Zzzz\AOX^Scer\UAS.cFa (but not Scer\NDI1^Scer\UAS.cSa) rescues pupal lethality in flies with expression of COX7A^KK110870 driven by Scer\GAL4^da.PU; surviving adults show progressive locomotor defects (climbing ability significantly reduced at 1 day old and more so at 14 days old) and bang sensitivity (significant increase in recovery time at 29[o]C at 1 day old and more so at 7 days old), compared to controls.

Co-expression of Zzzz\AOX^Scer\UAS.cFa partially suppresses climbing defects and bang sensitivity in flies with expression of COX7A^KK110870 driven by Scer\GAL4^elav-C155.

(Kemppainen et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106661

P{KK110870}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG9603^KK110870

COX7A^KK110870

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close