Amino acid replacement: Q15term.
C8320880T
Q15term | Poxm-PC
Q15term
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Homozygous and PoxmR361/Df(3R)159 larvae show severe defects in the somatic musculature.
In the ventral region of homozygous embryos, muscles VO4-VO6 are usually absent, whereas muscles VA1-VA3 are still present in most segments, but are poorly developed, lacking their normal shape and attachment sites. Muscles VL3 and VL4 are frequently abnormal or missing, whereas muscles VL1 and VL2 are occasionally or rarely affected. Muscles VO2 and VO1 are strongly and moderately disturbed, respectively. Muscle VT1 is often abnormal.
In the dorsolateral region of homozygous embryos, muscle DT1 is missing or abnormal in most cases, whereas muscle DO3 is mostly duplicated or abnormal and is very rarely missing. Muscles DA3 and DO4 are occasionally abnormal. Muscle LO1 is frequently missing. Muscle LT4 is frequently abnormal.
Dorsal muscles are unaffected in homozygous embryos.
The number of adult muscle precursors is altered in stage 14 homozygous embryos; the number of lateral LaPs increases to four to seven cells in each abdominal hemisegment, and more than two dorsolateral DLaPs are present in 20% of the segments. The number of dorsal DaPs and ventral VaPs is unaffected.
Df(1)sc19, PoxmR361 has muscle cell of A1-7 ventral longitudinal muscle 1 phenotype
Df(1)sc19, PoxmR361 has muscle cell of A1-7 ventral longitudinal muscle 2 phenotype
Df(1)sc19, PoxmR361 has muscle cell of A1-7 ventral longitudinal muscle 3 phenotype
Df(1)sc19, PoxmR361 has muscle cell of ventral acute muscle 3 phenotype
Df(1)sc19, PoxmR361 has muscle cell of A1-7 lateral transverse muscle 3 phenotype
Df(1)sc19, PoxmR361 has muscle cell of A1-7 lateral transverse muscle 4 phenotype
Df(1)sc19, PoxmR361 has A1-7 segment border muscle cell phenotype
Most muscles appeared to be affected independently by Poxm and l(1)sc in Df(1)sc19 PoxmR361 double mutant embryos, with some notable exceptions. Muscles VL1-VL3, SBM, VO1, VO2, DT1, LT3, LT4 and VA3 are more often absent in the double mutants. The more ventral and posterior a muscle is located within a segment, the more probable it is that it will show an enhanced phenotype in the double mutant.
