FlyBase Allele Report: Dmel\sxc[7]

General Information

Symbol

Dmel\sxc⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0239087

Feature type

allele

Associated gene

Dmel\sxc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Gambetta and Müller, 2014, Gambetta et al., 2009)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: K550term.

(Gambetta et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:5,326,699..5,326,699 [+]

Nucleotide change:

A5326699T

Reported nucleotide change:

A?T

Amino acid change:

K550term | sxc-PA; K550term | sxc-PB; K550term | sxc-PC

Reported amino acid change:

K550term

(Gambetta et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage

(Na et al., 2022)

decreased occurrence of cell division | adult stage

(Na et al., 2022)

fertile (with sxc²)

(Gambetta et al., 2009)

homeotic | embryonic stage | maternal effect

(Gambetta and Müller, 2014)

lethal - all die before end of P-stage (with Df(2R)nap1)

(Gambetta and Müller, 2009.8.18)

lethal - all die before end of P-stage (with sxc¹)

(Gambetta et al., 2009)

lethal - all die before end of P-stage (with sxc³)

(Gambetta et al., 2009)

lethal - all die before end of P-stage (with sxc⁴)

(Gambetta et al., 2009)

lethal - all die before end of P-stage (with sxc⁵)

(Gambetta et al., 2009)

some die during pharate adult stage (with Df(2R)nap1)

(Gambetta and Müller, 2009.8.18)

some die during pharate adult stage (with sxc¹)

(Gambetta et al., 2009)

some die during pharate adult stage (with sxc³)

(Gambetta et al., 2009)

some die during pharate adult stage (with sxc⁴)

(Gambetta et al., 2009)

some die during pharate adult stage (with sxc⁵)

(Gambetta et al., 2009)

viable (with sxc²)

(Gambetta et al., 2009)

Phenotype Manifest In

adult midgut epithelium

(Na et al., 2022)

adult midgut progenitor cell | decreased number

(Na et al., 2022)

embryonic/first instar larval cuticle | maternal effect

(Gambetta and Müller, 2014)

wing (with sxc²)

(Gambetta et al., 2009)

Detailed Description

Statement

Reference

Flies trans-heterozygous for sxc⁷ and sxc¹, sxc³, sxc⁴ or sxc⁵ develop into pharate adults showing a typical sxc mutant phenotype.

sxc²/sxc⁷ flies are viable and fertile, but exhibit wing abnormalities suggestive of wing-to-haltere transformations.

(Gambetta et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sxc⁵

(Gambetta et al., 2009)

sxc⁴

(Gambetta et al., 2009)

sxc³

(Gambetta et al., 2009)

sxc¹

(Gambetta et al., 2009)

Rescued by

sxc⁷ is rescued by sxc^{FRT.αTub84B.Tag:HA,Tag:FLAG}

(Gambetta and Müller, 2014)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

FlyBase Curator comment: The authors state that Df(2R)NC32 equates to the sxc⁷ point mutation. However, unresolved discrepancies between their data and that of Myster et al. (FBrf0174713) mean that it isn't appropriate or feasible to merge the Df(2R)NC32 and sxc⁷ reports at this time (August 2009).

(Gambetta et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Df(2R)NC32

(Gambetta and Müller, 2009.8.18, Gambetta et al., 2009)

scx⁷

(Gambetta et al., 2009)

sxc⁷

(Na et al., 2022, Akan et al., 2021, Akan et al., 2016, Gambetta and Müller, 2014, Gambetta and Müller, 2009.8.18, Gambetta et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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