FlyBase Allele Report: Dmel\KCNQ[JF02562]

General Information

Symbol

Dmel\KCNQ^JF02562

Species

D. melanogaster

Name

FlyBase ID

FBal0239263

Feature type

allele

Associated gene

Dmel\KCNQ

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02562}

Also Known As

uas-KCNQ-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

(Perkins et al., 2009.8.10)

Progenitor genotype

Carried in construct

P{TRiP.JF02562}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.8.10)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02562

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of KCNQ^JF02562 under the control of Scer\GAL4^elav-C155 in adults does not affect the threshold to heat-induced seizures, compared to controls.

(Hill et al., 2019)

Expression of KCNQ^JF02562 under the control of Scer\GAL4^SLC5A11.1.1 or Scer\GAL4^GMR38H02 in adults abolishes the significant decrease in preference for nutritive sugars seen in fed versus starved flies, compared to controls.

(Park et al., 2016)

Expression of KCNQ^JF02562 under the control of Scer\GAL4^elav.PU causes a significant impairment of initial 2 min memory and 1 hour memory compared to controls. Expression of KCNQ^JF02562 under the control of Scer\GAL4^c316, Scer\GAL4^ey-OK107, Scer\GAL4[Mef2.247] or Scer\GAL4^c305a leads to significant impairment of 1 hour memory, but not initial 2 min memory compared to controls. Expression of KCNQ^JF02562 under the control of Scer\GAL4^ey-OK107, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, also reduces 1 hour memory. Expression of KCNQ^JF02562 under the control of Scer\GAL4^ey-OK107 or Scer\GAL4^c316 does not cause alterations in olfactory acuity or shock reactivity compared to controls.