FlyBase Allele Report: Dmel\DEF8[JF02943]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\DEF8^JF02943

General Information

Symbol

Dmel\DEF8^JF02943

Species

D. melanogaster

Name

FlyBase ID

FBal0239448

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02943}

Also Known As

Def8 RNAi

Key Links

Genomic Maps

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02943}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior, with Scer\GAL4^elav.PU

(Oyarce-Pezoa et al., 2023)

melanotic necrosis | adult stage, with Scer\GAL4^GMR.PU

(Oyarce-Pezoa et al., 2023)

short lived, with Scer\GAL4^elav.PU

(Oyarce-Pezoa et al., 2023)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Oyarce-Pezoa et al., 2023)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

DEF8^JF02943, Scer\GAL4^GMR.PU is a suppressor of rhabdomere of eye photoreceptor cell | decreased number phenotype of Hsap\APP^{Aβ42.E693G.UAS.VTR}, Scer\GAL4^GMR.PU

(Oyarce-Pezoa et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

28312

y¹ v¹; P{TRiP.JF02943}attP2 e¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG11534^JF02943

DEF8^JF02943

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections