FlyBase Allele Report: Dmel\pbl[JF02979]

General Information

Symbol

Dmel\pbl^JF02979

Species

D. melanogaster

Name

FlyBase ID

FBal0239480

Feature type

allele

Associated gene

Dmel\pbl

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02979}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02979}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02979

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PLu

(Jeong et al., 2012)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^sca-537.4

(Jeong et al., 2012)

abnormal wound healing | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Nakamura et al., 2017)

decreased body size | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Jackson et al., 2024)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^elav.PLu

(Jeong et al., 2012)

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^sca-537.4

(Jeong et al., 2012)

Detailed Description

Statement

Reference

Wounded embryos expressing pbl^GL01092 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} show wound overexpansion, delayed actin accumulation around the wound edge and delayed repair, as compared to wounded control embryos.

(Nakamura et al., 2017)

Expression of pbl^JF02979 under the control of Scer\GAL4^sca-537.4 results in ISNb axons with increased fasciculation and defects in target recognition in 30.8% of hemisegments.

Expression of pbl^JF02979 under the control of Scer\GAL4^elav.PLu results in ISNb guidance defects in 41.2% of hemisegments.

(Jeong et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^ap-md544/pbl^JF02979 is an enhancer of abnormal size | third instar larval stage phenotype of Scer\GAL4^ap-md544, yki^UAS.cHa

(Gerlach et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^ap-md544/pbl^JF02979 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Scer\GAL4^ap-md544, yki^UAS.cHa

(Gerlach et al., 2018)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA/pbl^JF02979 is a non-suppressor of fat cell | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^JF02971

(Sun et al., 2019)

Scer\GAL4^Cg.PA/pbl^JF02979 is a non-suppressor of endoplasmic reticulum | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^JF02971

(Sun et al., 2019)

Other

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, pbl^JF02979 has centrosome | increased number | third instar larval stage phenotype

(Gerlach et al., 2018)

BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, pbl^JF02979 has wing disc dorsal compartment | third instar larval stage phenotype

(Gerlach et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of pbl^JF02979 enhances the third instar larval wing disc dorsal compartment enlargement induced by the expression of yki^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts].

(Gerlach et al., 2018)

Xenogenetic Interactions

Statement

Reference

The co-expression of pbl^JF02979 and BacA\p35^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] leads to a significant increase in the average number of centrosomes per cell in the third instar larval wing disc dorsal compartment, as compared to controls.

(Gerlach et al., 2018)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28343

y¹ v¹; P{TRiP.JF02979}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pbl^JF02979

pbl^RNAi(2)

(Nakamura et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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