FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lgr3JF03217
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General Information
Symbol
Dmel\Lgr3JF03217
Species
D. melanogaster
Name
FlyBase ID
FBal0239715
Feature type
allele
Associated gene
Dmel\Lgr3
Associated Insertion(s)
Carried in Construct
P{TRiP.JF03217}
Also Known As
Lgr3-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF03217}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF03217
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Lgr3JF03217 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4αTub84B.PL alleviates the growth inhibition of undamaged (anterior) tissues - eye discs - in third instar larvae (104 hr after egg laying, AEL) following targeted irradiation (limited to posterior tissues and administered in late second instar, at 80 hr AEL) which is observed in wild-type larvae and also strongly reduces the developmental delay the regenerative growth of damaged tissues normally produces.

      (Jaszczak et al., 2016)

      Expression of Lgr3JF03217 under the control of Scer\GAL4αTub84B.PL does not lead to any significant delay to pupariation, as compared to controls.

      (Garelli et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Lgr3JF03217 in neurons under the control of Scer\GAL4nSyb.PU suppresses the developmental delay caused by expression of Ilp8Ecol\lexAop.cCa in the imaginal tissues under the control of Ecol\lexArn-89-lexA.

      (Colombani et al., 2015)

      Co-expression of Lgr3JF03217 partially suppresses the developmental delay seen in flies expressing Ilp8Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4αTub84B.PL.

      (Garelli et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Lgr3JF03217
      Name Synonyms
      Secondary FlyBase IDs
        References (6)