FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NLazUAS.cHTa
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General Information
Symbol
Dmel\NLazUAS.cHTa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Hull-Thompson
FlyBase ID
FBal0239918
Feature type
allele
Associated gene
Dmel\NLaz
Associated Insertion(s)
Carried in Construct
P{UAS-NLaz.HT}
Key Links
Transgenic product class
cDNA
(Hull-Thompson et al., 2009)
wild_type
(Hull-Thompson et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hull-Thompson et al., 2009)
wild_type
(Hull-Thompson et al., 2009)
Mutagen
in vitro construct
(Hull-Thompson et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-NLaz.HT}
Cytology
Description

UASt regulatory sequences drive expression of a full-length NLaz cDNA.

(Hull-Thompson et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
NLaz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  spinocerebellar ataxia 1
      modeled by Hsap\ATXN182Q.UAS
      (Del Caño-Espinel et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing NLazScer\UAS.cHTa under the control of Scer\GAL4ppl.PP show increased tolerance to dry starvation conditions than wild-type controls.

      Animals expressing NLazScer\UAS.cHTa under the control of Scer\GAL4ppl.PP show increased tolerance to paraquat compared to controls.

      Animals expressing NLazScer\UAS.cHTa under the control of Scer\GAL4da.G32 show an increase in mean and maximum lifespan compared to controls

      (Hull-Thompson et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4ppl.PP/NLazUAS.cHTa is a suppressor of abnormal stress response phenotype of hep1

      (Hull-Thompson et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased sensitivity of hep1/Y animals to dry starvation is suppressed by expression of NLazScer\UAS.cHTa under the control of Scer\GAL4ppl.PP.

      The depletion of nutrient stores (lipids and carbohydrates) seen in hep1/Y animals upon wet starvation is suppressed by expression of NLazScer\UAS.cHTa under the control of Scer\GAL4ppl.PP.

      Expression of NLazScer\UAS.cHTa under the control of Scer\GAL4ppl.PP can not further increase the starvation resistance of chico1/+ flies.

      (Hull-Thompson et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NLazScer\UAS.cHTa
      NLazUAS.cHTa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hull-Thompson
      Secondary FlyBase IDs
        References (2)