FlyBase Allele Report: Dmel\modSP[1]

General Information

Symbol

Dmel\modSP¹

Species

D. melanogaster

Name

FlyBase ID

FBal0240603

Feature type

allele

Associated gene

Dmel\modSP

Associated Insertion(s)

TI{TI}modSP¹

Carried in Construct

Also Known As

modSP^KO

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Buchon et al., 2009)

Mutagen

recombination

(Buchon et al., 2009)

I-SceI

(Buchon et al., 2009)

FLPase

(Buchon et al., 2009)

ends-out gene targeting

(Buchon et al., 2009)

Progenitor genotype

Associated Insertion(s)

TI{TI}modSP¹

Cytology

Description

The entire modSP locus has been replaced by a w^+mW.hs marker.

(Buchon et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

sequence_alteration

3R:16,652,617..16,655,629 [-]

Comment:

3 kb has been deletied from modSP and replaced with a mini-white gene by homologous recombination.

(Buchon et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Fullaondo et al., 2011, Buchon et al., 2009)

abnormal immune response (with Df(3R)P-10)

(Buchon et al., 2009)

abnormal immune response (with Df(3R)Spf)

(Buchon et al., 2009)

abnormal immune response | larval stage

(Kanoh et al., 2021)

increased mortality | larval stage | conditional

(Kanoh et al., 2021)

viable

(Buchon et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

modSP¹ larvae show increased susceptibility (i.e. mortality) to Candida glabrata fungal infection.

(Kanoh et al., 2021)

Mutant flies show reduced survival compared to wild-type controls after natural infection with B. bassiana.

(Fullaondo et al., 2011)

modSP¹ mutants are viable and exhibit no visible developmental defects.

When challenged by a range of gram-positive bacteria (E. faecalis, L. monocytogenes), modSP¹ flies rapidly succumb to infection. However, modSP¹ mutants do not cause a general immune deficiency, because modSP¹ flies exhibit a wild-type survival to a septic injury with the Gram-negative bacteria Erwinia carotovora, which is known to activate the Imd pathway.

modSP¹ mutant flies rapidly succumb to C.albicans infection.

modSP¹ flies exhibit a moderate increase of susceptibility to Aspergillus fumigatus infection compared with wild-type.

modSP¹/Df(3R)P-10 and modSP¹/Df(3R)Spf flies rapidly succumb to infection.

modSP^1.Δ.w mutants are viable and exhibit no visible developmental defects.

When challenged by a range of gram-positive bacteria (E. faecalis, L. monocytogenes), modSP^1.Δ.w flies rapidly succomb to infection. However, modSP^1.Δ.w mutants do not cause a general immune deficiency, because modSP^1.Δ.w flies exhibit a wild-type survival to a septic injury with the Gram-negative bacteria Erwinia carotovora, which is known to activate the Imd pathway.

modSP^1.Δ.w mutant flies rapidly succomb to C.albicans infection.

modSP^1.Δ.w flies exhibit a moderate increase of susceptibility to Aspergillus fumigatus infection compared with wild-type.

modSP^1.Δ.w/Df(3R)P-10 and modSP^1.Δ.w/Df(3R)Spf flies rapidly succumb to infection.

(Buchon et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

modSP¹ is an enhancer of abnormal immune response phenotype of psh¹

(Buchon et al., 2009)

Other

Statement

Reference

modSP¹, psh¹ has abnormal immune response | adult stage phenotype

(Kanoh et al., 2021)

modSP¹, psh¹ has abnormal immune response | larval stage phenotype

(Kanoh et al., 2021)

modSP¹, psh¹ has increased mortality | adult stage | conditional phenotype

(Kanoh et al., 2021)

modSP¹, psh¹ has increased mortality | larval stage | conditional phenotype

(Kanoh et al., 2021)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

modSP¹, psh¹ double mutant larvae and adults show increased susceptibility (i.e. mortality) to Candida glabrata fungal infection.

(Kanoh et al., 2021)

psh¹ ; modSP^1.Δ.w double mutant flies exhibit a moderate increase of susceptibility to Aspergillus fumigatus infection compared with single mutants.

psh¹ ; modSP¹ double mutant flies exhibit a moderate increase of susceptibility to Aspergillus fumigatus infection compared with single mutants.

(Buchon et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

55717

w^*; TI{TI}modSP¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ModSP¹

(Iatsenko et al., 2020, Dudzic et al., 2019, Dostálová et al., 2017)

ModSP^KO

(Nainu et al., 2024)

modSP^1.Δ.w

modSP¹

(Song et al., 2026, Nakano et al., 2023, Troha et al., 2019, Alpar et al., 2018, Louradour et al., 2017, Buchon et al., 2009)

modSP^KO

(Kenmoku et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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