FlyBase Allele Report: Dmel\psh[1]

General Information

Symbol

Dmel\psh¹

Species

D. melanogaster

Name

FlyBase ID

FBal0138177

Feature type

allele

Associated gene

Dmel\psh

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ligoxygakis et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: H187Y. Nucleotide substitution: C?T.

(Ligoxygakis et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:18,485,391..18,485,391 [-]

Nucleotide change:

C18485391T

Reported nucleotide change:

C?T

Amino acid change:

H187Y | psh-PA

Reported amino acid change:

H187Y

Comment:

Same mutation as psh⁴

(Ligoxygakis et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Buchon et al., 2009, Ligoxygakis et al., 2002)

abnormal immune response | larval stage

(Kanoh et al., 2021)

increased mortality | larval stage | conditional

(Kanoh et al., 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

psh¹ larvae show increased susceptibility (i.e. mortality) to Candida glabrata fungal infection.

(Kanoh et al., 2021)

psh¹ flies exhibit a moderate increase of susceptibility to Aspergillus fumigatus infection compared with wild-type.

(Buchon et al., 2009)

psh¹ flies are highly susceptible to fungal infection (B.bassiana), but show a wild-type pattern of survival after infection with Gram-positive bacteria (E.faecalis previously known as 'Streptococcus faecalis') and are resistant to Gram-negative bacterial infection.

(Ligoxygakis et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

psh¹ has abnormal immune response phenotype, enhanceable by modSP¹

(Buchon et al., 2009)

Suppressor of

Statement

Reference

psh¹ is a suppressor of short lived phenotype of nec¹/nec²

(Ligoxygakis et al., 2002)

Other

Statement

Reference

modSP¹, psh¹ has abnormal immune response | adult stage phenotype

(Kanoh et al., 2021)

modSP¹, psh¹ has abnormal immune response | larval stage phenotype

(Kanoh et al., 2021)

modSP¹, psh¹ has increased mortality | adult stage | conditional phenotype

(Kanoh et al., 2021)

modSP¹, psh¹ has increased mortality | larval stage | conditional phenotype

(Kanoh et al., 2021)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

modSP¹, psh¹ double mutant larvae and adults show increased susceptibility (i.e. mortality) to Candida glabrata fungal infection.

(Kanoh et al., 2021)

psh¹ ; modSP¹ double mutant flies exhibit a moderate increase of susceptibility to Aspergillus fumigatus infection compared with single mutants.

(Buchon et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a suppressor of the nec mutant phenotype.

(Ligoxygakis et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Psh¹

(Tang et al., 2025, Nainu et al., 2024)

psh¹

(Song et al., 2026, Luo et al., 2025, Troha et al., 2019, Alpar et al., 2018, Issa et al., 2018, Dostálová et al., 2017, Kenmoku et al., 2017, Louradour et al., 2017, Buchon et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

Open Close