FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\thse02026
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General Information
Symbol
Dmel\thse02026
Species
D. melanogaster
Name
FlyBase ID
FBal0241059
Feature type
allele
Associated gene
Dmel\ths
Associated Insertion(s)
PBac{RB}thse02026
Carried in Construct
Also Known As
ths02026
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Franzdóttir et al., 2009)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{RB}thse02026
    Cytology
    Description

    Insertion in the second intron.

    (Kadam et al., 2009)
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{RB}
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        ths759/thse02026 transheterozygotes show a decrease in the number of ensheathing glial cells and overall reduction of their processes in the developing antennal lobes during late pupal stages.

        (Wu et al., 2017)

        Glial fail to wrap individual axon fascicles in the developing eye in homozygotes and in thse02026/Df(2R)BSC25 animals.

        (Franzdóttir et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        thse02026 has glial cell phenotype, suppressible by pyrd06722/Scer\GAL4GMR.long

        (Franzdóttir et al., 2009)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of pyrd06722 under the control of Scer\GAL4GMR.long rescues the failure of thse02026/thse02026 glia to wrap photoreceptor axons.

        (Franzdóttir et al., 2009)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        ths02026
        (Avet-Rochex et al., 2012, Kadam et al., 2009, Klingseisen et al., 2009)
        thsP02026
        thse02026
        (Rothenbusch-Fender et al., 2017, Wu et al., 2017, Irizarry and Stathopoulos, 2015, Franzdóttir et al., 2009)
        thse02
        (Wu et al., 2017)
        Name Synonyms
        Secondary FlyBase IDs
        • FBal0222602
        • FBal0239037
        References (8)