FlyBase Allele Report: Dmel\Exn[EY-Δ23]

General Information

Symbol

Dmel\Exn^EY-Δ23

Species

D. melanogaster

Name

FlyBase ID

FBal0241207

Feature type

allele

Associated gene

Dmel\Exn

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Frank et al., 2009)

Mutagen

Delta2-3 transposase

(Frank et al., 2009)

Progenitor genotype

P{EPgy2}Exn^EY01953

(Frank et al., 2009)

Cytology

Description

A deletion resulting from the imprecise excision of P{EPgy2}Exn^EY01953 removing a large portion of Exn.

(Frank et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:16,991,025..16,992,325 [+]

Comment:

Deletion resulting from the imprecise excsion of P{EPgy2}Exn^EY01953. The endpoints were estimated from the graph and sequence in Figure 1. The second breakpoint is in an intron but the location within the intron was not reported.

(Frank et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Exn[+]/Exn^EY-Δ23 is a non-enhancer of abnormal neurophysiology | third instar larval stage | recessive phenotype of GluRIIA^SP16

(Frank et al., 2009)

NOT Suppressor of

Statement

Reference

Exn[+]/Exn^EY-Δ23 is a non-suppressor of abnormal neurophysiology | recessive | third instar larval stage phenotype of GluRIIA^SP16

(Frank et al., 2009)

Other

Statement

Reference

Exn^EY-Δ23, GluRIIA^SP16, cac^S/cac[+] has abnormal neurophysiology | recessive | third instar larval stage phenotype

(Frank et al., 2009)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Exn[+]/Exn^EY-Δ23 is a non-enhancer of embryonic/larval neuromuscular junction phenotype of GluRIIA^SP16

(Frank et al., 2009)

NOT Suppressor of

Statement

Reference

Exn[+]/Exn^EY-Δ23 is a non-suppressor of embryonic/larval neuromuscular junction phenotype of GluRIIA^SP16

(Frank et al., 2009)

Other

Statement

Reference

Exn^EY-Δ23, GluRIIA^SP16 has NMJ bouton phenotype

(Frank et al., 2009)

Exn^EY-Δ23, GluRIIA^SP16, cac^S/cac[+] has embryonic/larval neuromuscular junction phenotype

(Frank et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

GluRIIA^SP16 mutant larvae, also homozygous for an Exn^EY-Δ23 allele, show a slight but significant increase in bouton number at the NMJ compared to GluRIIA^SP16 single mutants.

GluRIIA^SP16 mutant larvae, also homozygous for an Exn^EY-Δ23 allele, show no difference in average active zone number per NMJ compared to GluRIIA^SP16 single mutants.

The recessive GluRIIA^SP16 single mutant NMJ synaptic homeostasis phenotype is not enhanced nor suppressed by a heterozygous Exn^EY-Δ23 mutation.

The recessive GluRIIA^SP16 single mutant NMJ synaptic homeostatic response is completely suppressed in the presence of a heterozygous cac^S/+ mutation in combination with an Exn^EY-Δ23/+ heterozygous genetic background.

(Frank et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Exn^EY-Δ23 is rescued by Scer\GAL4^elav-C155/Exn^UAS.EYFP

(Frank et al., 2009)

Comments

Presynaptic expression of Exn^{Scer\UAS.T:Avic\GFP-EYFP} driven by the pan-neuronal driver Scer\GAL4^elav-C155 in a GluRIIA^SP16; Exn^EY-Δ23 double mutant background is sufficient to fully rescue the Exn^EY-Δ23 specific components in the abnormal neuromuscular junction synaptic homeostasis phenotypes associated with GluRIIA^SP16; Exn^EY-Δ23 double mutants.

(Frank et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Exn^EY-Δ23

exn^EY-Δ23

(Frank et al., 2009)

exn^EYΔ23

(Sekine et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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