FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sloMB11481
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General Information
Symbol
Dmel\sloMB11481
Species
D. melanogaster
Name
FlyBase ID
FBal0241284
Feature type
allele
Associated gene
Dmel\slo
Associated Insertion(s)
Mi{ET1}sloMB11481
Carried in Construct
Also Known As
slo11481
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Jepson et al., 2014)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}sloMB11481
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous third instar larvae show a significant increase in bouton size at the neuromuscular junction compared to controls. Bouton number is normal.

        Mutant larvae show a significant increase in evoked excitatory junctional current amplitude and width compared to controls. There is a significant increase in spontaneous miniature EJC frequency compared to controls.

        (Jepson et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhanced by
        Statement
        Reference

        sloMB11481 has abnormal neurophysiology | third instar larval stage phenotype, non-enhanceable by dyscc03838

        (Jepson et al., 2014)
        NOT suppressed by
        Statement
        Reference

        sloMB11481 has abnormal neurophysiology | third instar larval stage phenotype, non-suppressible by dyscc03838

        (Jepson et al., 2014)
        NOT Enhancer of
        Statement
        Reference

        sloMB11481 is a non-enhancer of abnormal neurophysiology | third instar larval stage phenotype of dyscc03838

        (Jepson et al., 2014)
        NOT Suppressor of
        Statement
        Reference

        sloMB11481 is a non-suppressor of abnormal neurophysiology | third instar larval stage phenotype of dyscc03838

        (Jepson et al., 2014)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        sloMB11481 is a suppressor | partially of NMJ bouton phenotype of dyscs168

        (Jepson et al., 2014)

        sloMB11481 is a suppressor of NMJ bouton phenotype of dyscc03838

        (Jepson et al., 2014)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Bouton size at the neuromuscular junction in dyscs168 sloMB11481 double mutant larvae is significantly increased compared to wild type, but is not significantly different from that seen in dyscs168 single mutants. The reduction in bouton number at the neuromuscular junction seen in dyscs168 larvae is suppressed in dyscs168 sloMB11481 double mutant larvae.

        Bouton size at the neuromuscular junction in dyscc03838 sloMB11481 double mutant larvae is significantly increased compared to wild type, but is not significantly different from that seen in dyscc03838 single mutants. The reduction in bouton number at the neuromuscular junction seen in dyscc03838 larvae is suppressed in dyscc03838 sloMB11481 double mutant larvae.

        Evoked excitatory junctional currents (EJCs) in dyscc03838 sloMB11481 double mutant larvae have the same phenotypes as in either single mutant. Miniature EJC frequency in dyscc03838 sloMB11481 double mutant larvae is not significantly different from that in either single mutant.

        (Jepson et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        sloMB11481 is rescued by slohs.B52H

        (Jepson et al., 2014)
        Comments

        Expression of slohs.B52H rescues the increase in bouton size at the neuromuscular junction seen in sloMB11481 larvae.

        (Jepson et al., 2014)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        slo11481
        (Lowe et al., 2024, Jepson et al., 2014)
        sloMB11481
        (Bellen, 2010.1.28)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)