FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\uif1
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General Information
Symbol
Dmel\uif1
Species
D. melanogaster
Name
FlyBase ID
FBal0241440
Feature type
allele
Associated gene
Dmel\uif
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhang and Ward, 2009)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q2407term.

(Zhang and Ward, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,977,795..6,977,795 [-]
Nucleotide change:

C6977795T

Reported nucleotide change:

C29974T

Amino acid change:

Q2407term | uif-PB; Q2407term | uif-PC; Q2407term | uif-PD; Q2407term | uif-PE; Q2407term | uif-PF; Q2407term | uif-PG

Reported amino acid change:

Q2407term

Comment:

Reported position of nucleotide change is relative to GB:AC008326.

(Zhang and Ward, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  muscular dystrophy
      modeled by DgO86
      (Kucherenko et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      FlyBase curator comment: Interactions with Dg[086] and/or Dg[323] were detected in a Dg[086]/+ or Dg[323]/+ background which exhibits no obvious changes in muscle morphology. Nonetheless, these interactions have been captured as 'modifier' ('exacerbates') annotations here to best capture the experimental finding and the authors' intention.

      (Kucherenko et al., 2011)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous uif1 mutant flies exhibit increased indirect flight muscle degeneration compare to controls.

      (Kucherenko et al., 2011)

      Mutants show primarily larva lethality characterised by poorly inflated tracheae.

      (Zhang and Ward, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      uif[+]/uif1 is a non-enhancer of indirect flight muscle cell phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2011)

      uif[+]/uif1 is a non-enhancer of indirect flight muscle cell phenotype of DgRNAi.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2011)
      Other
      Statement
      Reference

      Dg[+]/DgO86, uif1 has indirect flight muscle cell phenotype

      (Kucherenko et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      uif Dys double heterozygous flies (uif1/Df(3R)Exel6184) do not exhibit indirect flight muscle degeneration.

      uif1 DgO86 double heterozygous flies exhibit indirect flight muscle degeneration.

      One copy of uif1 does not enhance the indirect flight muscle degeneration seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

      One copy of uif1 does not enhance the indirect flight muscle degeneration seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

      uif1 Dg323 double heterozygous flies do not exhibit indirect flight muscle degeneration.

      (Kucherenko et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: Mcr1.

      (Hall et al., 2014)

      The uif1 allele is a second site mutation on the E(br)155Ebr155 chromosome. It has not been possible to recombine the two mutations aprt.

      (Zhang and Ward, 2009)

      The Mcr1 and uif1 mutations were originally recovered on the same "E(br)155" chromosome. The two mutations have been recombined apart.

      (Hall et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sp1070UifE(Br)155
      (Kucherenko et al., 2011)
      uif1
      (Zhang and Ward, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)