FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fas1+3.UAS
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General Information
Symbol
Dmel\Fas1+3.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241454
Feature type
allele
Associated gene
Dmel\Fas1
Associated Insertion(s)
Carried in Construct
P{UAS-Fas1.+3}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kristiansen et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Fas1.+3}
Cytology
Description

UASt regulatory sequences drive expression of Fas1 cDNA coding sequences.

(Kristiansen et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Fas1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Fas1+3.Scer\UAS driven by Scer\GAL4Tab2-201Y does not affect pruning of mushroom body γ neurons.

      (Bornstein et al., 2015)

      Scer\GAL4MS1075-driven overexpression of Fas1+3.Scer\UAS causes frequent and stronger alterations in ocellar sensory system axon guidance (52% and 42% for OP and BM axons, respectively), revealing that its overexpression is detrimental during ocellar sensory system axon guidance. Most of these alterations consist of OP axons failing to enter the brain at the correct choice point.

      Expression of Fas1+3.Scer\UAS under the control of Scer\GAL4Bx-MS1096 induces few phenotypic alterations. No ectopic expression alterations are found in the ocellar sensory system and only a weak gain of function phenotype is observed in the wing.

      (Kristiansen et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of bskDN.Scer\UAS.cUa with Fas1+3.Scer\UAS driven by Scer\GAL4Tab2-201Y results in mushroom body γ lobe pruning defects.

      (Bornstein et al., 2015)

      Fas1+3.Scer\UAS overexpression under the control of Scer\GAL4MS1075 can rescue the Nrgl3 phenotype at the restrictive temperature, including OP axon alterations. Expression of Fas1+3.Scer\UAS does not modify the Nrg loss-of-function axonal alterations and causes a phenotype that reflects a summation of the Fas1 gain-of-function and the Nrgl3 loss-of-function.

      (Kristiansen et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fas1+3.Scer\UAS
      Fas1+3.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)