FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sec24CDG200
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General Information
Symbol
Dmel\Sec24CDG200
Species
D. melanogaster
Name
FlyBase ID
FBal0241514
Feature type
allele
Associated gene
Dmel\Sec24CD
Associated Insertion(s)
Carried in Construct
Also Known As
stenG200
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Forster et al., 2010)
Mutagen
ethyl methanesulfonate
(Forster et al., 2010)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q785term.

(Forster et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,233,407..2,233,407 [-]
Nucleotide change:

C2233407T

Amino acid change:

Q785term | Sec24CD-PA; Q785term | Sec24CD-PB; Q785term | Sec24CD-PC

Reported amino acid change:

Q785term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Forster et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ghoG200 mutant embryos have narrow tracheal lumina with small apical cell surfaces. Dorsal trunk length is only slightly reduced compared to controls. ghoG200 mutant dorsal trunk cells compensate for their smaller surface by stretching axially.

      (Förster and Luschnig, 2012)

      Ventral denticle belts are absent in mutant embryos and the head skeleton is strongly reduced and is unpigmented.

      (Forster et al., 2010)

      The dorsal trunk lumen is narrow in stage 16 stenG200/stenH24 embryos.

      Cells of the tracheal dorsal trunk show conical profiles at stage 16 in mutant embryos, with a small, convex apical surface lacking cuticular taenidia, and the entire lumen is filled with matrix material. The endoplasmic reticulum lumen is dramatically enlarged compared to wild type. Basolateral septate junctions are still present.

      (Forster et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased diameter of the dorsal trunk lumen that is seen in embryos expressing crbScer\UAS.cWa under the control of Scer\GAL4btl.PS is suppressed in a stenG200 background.

      (Forster et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sec24CDG200
      ghoG200
      stenG200
      (Förster and Luschnig, 2012, Forster et al., 2010, Forster et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)