FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Sec24CD
Open Close
General Information
Symbol
Dmel\Sec24CD
Species
D. melanogaster
Name
Secretory 24CD
Annotation Symbol
CG10882
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262126
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Secretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

sten, gho, stenosis, ghost, Sec24

Key Links
Genomic Location
Cytogenetic map
22D4-22D5
Sequence location
Recombination map
2-5
RefSeq locus
NT_033779 REGION:2231106..2236844
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables SNARE binding
inferred from biological aspect of ancestor with PANTHER:PTN000351470
(GO Reference Genome Project, 2011-)
enables zinc ion binding
inferred from biological aspect of ancestor with PANTHER:PTN000351470
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006895, InterPro:IPR036174
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
acts_upstream_of_positive_effect chitin-based cuticle development
inferred from mutant phenotype
(Norum et al., 2010)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from mutant phenotype
(Norum et al., 2010)
involved_in extracellular matrix constituent secretion
inferred from mutant phenotype
(Norum et al., 2010)
acts_upstream_of_positive_effect lumen formation, open tracheal system
inferred from mutant phenotype
(Norum et al., 2010)
involved_in protein localization to cell surface
inferred from mutant phenotype
(Norum et al., 2010)
involved_in protein localization to plasma membrane
inferred from mutant phenotype
(Kumichel et al., 2015)
involved_in protein secretion
inferred from mutant phenotype
(Forster et al., 2010, Norum et al., 2010)
involved_in regulation of tube diameter, open tracheal system
inferred from mutant phenotype
(Forster et al., 2010)
involved_in regulation of tube size, open tracheal system
inferred from mutant phenotype
(Forster et al., 2010)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in COPII-coated vesicle cargo loading
inferred from biological aspect of ancestor with PANTHER:PTN000351470
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with SGD:S000001371
(Gene Ontology Curators, 2002-)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
(InterPro Project Members, 2004-)
involved_in intracellular protein transport
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of COPII vesicle coat
inferred from mutant phenotype
(Norum et al., 2010)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Forster et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of COPII vesicle coat
inferred from biological aspect of ancestor with PANTHER:PTN000351470
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with SGD:S000001371
(Gene Ontology Curators, 2002-)
(InterPro Project Members, 2004-)
is_active_in endoplasmic reticulum exit site
inferred from biological aspect of ancestor with PANTHER:PTN000351470
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Secretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
COAT PROTEIN COMPLEX II -
The Coat Protein Complex II (COPII) mediates protein transport from the ER to Golgi (anterograde transport). COPII recruitment is initiated by the activation of the small GTPase Sar1. Sar1 recruits a heterodimeric complex comprising of Sec23/24, which interacts with cargo and the outer cage - a heterotetramer composed of Sec13/31. (Adapted from PMID:18060556).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
gho: ghost
Homozygous lethal; embryonic cuticle undifferentiated.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Sec24CD for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PC99)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sec24CD-RA
FBtr0077810
NM_134820
4155
1193
Sec24CD-RB
FBtr0329964
NM_001272988
4827
1193
Sec24CD-RC
FBtr0329965
NM_001272989
4155
1231
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sec24CD-PA
FBpp0077487
129.3
1193
7.27
Q9VQ94
NP_608664
AAF51283
Sec24CD-PB
FBpp0302999
129.3
1193
7.27
Q9VQ94
NP_001259917
AGB92454
Sec24CD-PC
FBpp0303000
133.7
1231
8.03
M9PC99
NP_001259918
AGB92455
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1193 aa isoforms: Sec24CD-PA, Sec24CD-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sec24CD using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.19

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa primordium
(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
garland cell primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of COPII vesicle coat
inferred from mutant phenotype
(Norum et al., 2010)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Forster et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sec24CD in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sec24CD
Transgenic constructs containing regulatory region of Sec24CD
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of first instar larval stage
lethal - all die before end of first instar larval stage (with Df(2L)BSC688)
lethal - all die before end of first instar larval stage (with Df(2L)Exel7010)
lethal - all die before end of first instar larval stage (with Sec24CD1)
lethal - all die before end of first instar larval stage (with Sec24CDIP)
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage
lethal - all die during embryonic stage | recessive
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell adhesion | first instar larval stage
abnormal cell polarity | late embryonic stage
abnormal cell shape | embryonic stage
abnormal cell shape | first instar larval stage
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during embryonic stage
some die during embryonic stage | recessive
some die during first instar larval stage
some die during first instar larval stage (with Df(2L)BSC688)
some die during first instar larval stage (with Df(2L)Exel7010)
some die during first instar larval stage (with Sec24CD1)
some die during first instar larval stage (with Sec24CDIP)
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adherens junction
basement membrane
cephalopharyngeal skeleton
cephalopharyngeal skeleton (with Df(2L)BSC688)
cephalopharyngeal skeleton (with Df(2L)Exel7010)
cephalopharyngeal skeleton (with Sec24CD1)
cephalopharyngeal skeleton (with Sec24CDIP)
denticle
denticle (with Df(2L)BSC688)
denticle (with Df(2L)Exel7010)
denticle (with Sec24CD1)
denticle (with Sec24CDIP)
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle (with Df(2L)BSC688)
embryonic/first instar larval cuticle (with Df(2L)Exel7010)
embryonic/first instar larval cuticle (with Sec24CD1)
embryonic/first instar larval cuticle (with Sec24CDIP)
embryonic/larval epidermis
embryonic/larval tracheal dorsal trunk
embryonic/larval tracheal dorsal trunk | embryonic stage 17
embryonic/larval tracheal section
embryonic/larval tracheal section (with Df(2L)BSC688)
embryonic/larval tracheal section (with Df(2L)Exel7010)
embryonic/larval tracheal section (with Sec24CD1)
embryonic/larval tracheal section (with Sec24CDIP)
embryonic/larval tracheal section | first instar larval stage
embryonic dorsal epidermis
endoplasmic reticulum | late embryonic stage
endoplasmic reticulum lumen & embryonic dorsal trunk
epicuticle
filopodium & embryonic leading edge cell
Golgi apparatus | embryonic stage 16
larval apodeme
male germ cell nucleus | increased number, with Scer\GAL4VP16.bam
rough endoplasmic reticulum & embryonic dorsal epidermis
septate junction
spermatid, with Scer\GAL4VP16.bam
taenidial fold | first instar larval stage
taenidium
tracheal dorsal trunk primordium
tracheal dorsal trunk primordium (with Sec24CDG200)
tracheal dorsal trunk primordium (with Sec24CDH24)
ventral denticle belt
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\SEC24C
12 of 14
Yes
Yes
Hsap\SEC24D
12 of 14
Yes
Yes
Hsap\SEC24A
3 of 14
No
No
Hsap\SEC24B
3 of 14
No
No
Hsap\SEC23A
1 of 14
No
No
Hsap\SEC23B
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (6)
Rnor\Sec24c
12 of 14
Yes
Yes
Rnor\Sec24d
12 of 14
Yes
Yes
Rnor\Sec24a
3 of 14
No
No
Rnor\Sec24b
3 of 14
No
No
Rnor\Sec23a
1 of 14
No
No
Rnor\Sec23b
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Sec24c
12 of 14
Yes
Yes
Mmus\Sec24d
12 of 14
Yes
Yes
Mmus\Sec24a
3 of 14
No
No
Mmus\Sec24b
3 of 14
No
No
Mmus\Sec23a
1 of 14
No
No
Mmus\Sec23b
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\anxa2
9 of 13
Yes
Yes
Xtro\sec24c
9 of 13
Yes
Yes
Xtro\sec24d
8 of 13
No
Yes
Xtro\sec24b
2 of 13
No
No
Xtro\josd1
1 of 13
No
No
Xtro\sec23a
1 of 13
No
No
Xtro\sec23b
1 of 13
No
No
Xtro\sgta
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\sec24c
12 of 14
Yes
Yes
Drer\sec24d
11 of 14
No
Yes
Drer\sec24b
3 of 14
No
No
Drer\sec24a
2 of 14
No
No
Drer\sec23a
1 of 14
No
No
Drer\sec23b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\sec-24.1
13 of 14
Yes
Yes
Cele\sec-24.2
3 of 14
No
No
Cele\sec-23
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP008803
4 of 12
Yes
Yes
Agam\AgaP_AGAP005263
3 of 12
No
No
Agam\AgaP_AGAP001759
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\AT4G32640
11 of 13
Yes
Yes
Atha\CEF
11 of 13
Yes
Yes
Atha\ERMO2
4 of 13
No
No
Atha\AT2G27460
2 of 13
No
No
Atha\AT1G05520
1 of 13
No
No
Atha\AT2G21630
1 of 13
No
No
Atha\AT3G23660
1 of 13
No
No
Atha\AT4G01810
1 of 13
No
No
Atha\AT4G14160
1 of 13
No
No
Atha\AT5G43670
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\SFB3
10 of 13
Yes
Yes
Scer\SEC24
4 of 13
No
No
Scer\SFB2
4 of 13
No
No
Scer\NEL1
1 of 13
No
No
Scer\SEC23
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPBC4.03c
12 of 12
Yes
Yes
Spom\sec24
3 of 12
No
No
Spom\sec231
1 of 12
No
No
Spom\sec2302
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sec24CD. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
Sec24AB
4 of 13
Sec23
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    SEC24D; SEC24 homolog D, COPII component
    model of  Cole-Carpenter syndrome
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SEC24C; SEC24 homolog C, COPII component
    12 of 14
    607185
        SEC24D; SEC24 homolog D, COPII component
        12 of 14
        607186
        SEC24A; SEC24 homolog A, COPII component
        3 of 14
        607183
            SEC24B; SEC24 homolog B, COPII component
            3 of 14
            607184
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Sec24CD - crb
                anti tag coimmunoprecipitation, anti tag western blot
                (Kumichel et al., 2015)
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                cactin
                suppressible
                Sec24CD
                (Miao et al., 2022)
                crb
                suppressible
                Sec24CD
                (Forster et al., 2010)
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map
                2-5
                Cytogenetic map
                22D4-22D5
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                22D4-22D5
                Limits computationally determined from genome sequence between P{lacW}s4989 and P{lacW}Rab5k08232
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                2-5

                (FlyBase, 2016)

                2-4.5

                (Comeron et al., 2012)

                2-68

                (Tearle and Nusslein-Volhard, 1987)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (8)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (53)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: sten CG10882

                      (Forster et al., 2010)

                      Source for merge of: gho sten

                      (Norum et al., 2010)

                      Source for merge of: CG10882 BcDNA:LP05220

                      (FlyBase, 1996-)
                      Additional comments

                      FlyBase curator comment: the insertion in the "f06847" Exelixis line (PBac{WH}CG31679f06847) was originally assigned to the CG10882 gene in FBrf0179797, resulting in the "CG10882f06847" (FBal0162641) allele. However, FBrf0184340 shows that the insertion is actually within CG31679.

                      (Bloomington Drosophila Stock Center, 2004.11.6)

                      Source for merge of CG10882 BcDNA:LP05220 was a shared cDNA ( date:020730 ).

                      (FlyBase, 1996-)
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: Sec24CD gho

                      (FlyBase, 2009-)
                      Nomenclature comments

                      Renamed from 'gho' to 'Sec24CD' to better indicate the presence of two SEC24 orthologs in D. melanogaster, and to specifically reflect the orthology of this gene to SEC24C and SEC24D of humans (see OrthoDB orthologs and FBrf0210959).

                      (FlyBase, 2009-)
                      Etymology

                      The gene is named "stenosis" based on the narrow tracheal lumen phenotype of mutants.

                      (Forster et al., 2010)

                      Named "Sec24CD" after the human orthologs.

                      (FlyBase, 2009-)
                      Synonyms and Secondary IDs (16)
                      Reported As
                      Symbol Synonym
                      BcDNA:LP05220
                      CG10882
                      (National Institute of Genetics Fly Stocks, 2022-, Jiang, 2019.3.1, Hosono et al., 2015, Zacharogianni et al., 2014, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, D'Ambrosio and Vale, 2010, Forster et al., 2010, Norum et al., 2010, Costello et al., 2009, Hazelett et al., 2009, Keleman et al., 2009.8.5, Beller et al., 2008, Shah et al., 2008, Beller et al., 2006, Liebl et al., 2006)
                      FBgn0031408
                      (Costello et al., 2009)
                      Gho
                      (Moussian, 2013)
                      Sec24
                      (Camelo and Luschnig, 2021, Norum et al., 2010)
                      Sec24CD
                      (Matsuura et al., 2024, Lee et al., 2023, Bourne et al., 2022, Miao et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Levis, 2018.8.30, Transgenic RNAi Project members, 2017-, Öztürk-Çolak et al., 2016, Roman-Fernandez and Bryant, 2016, Kumichel et al., 2015, Zacharogianni et al., 2014, Norum et al., 2010)
                      Sten
                      (Zacharogianni et al., 2014, Iyer et al., 2013)
                      gho
                      (Kumichel et al., 2015, Kwon et al., 2013, Förster and Luschnig, 2012, Friedman et al., 2011, Norum et al., 2010)
                      sec24
                      (Neumüller et al., 2013)
                      sfb3
                      (Neumann et al., 2010)
                      sten
                      (Kumichel et al., 2015, Förster and Luschnig, 2012, Forster et al., 2010, Forster et al., 2010, Armbruster et al., 2007)
                      Name Synonyms
                      Ghost
                      (Juarez, 2016, Moussian, 2013, Norum et al., 2010)
                      Sec24CD ortholog
                      Secretory 24CD
                      ghost
                      (Wieschaus and Nüsslein-Volhard, 2016, Juarez et al., 2011, Norum et al., 2010)
                      stenosis
                      (Kumichel et al., 2015, Juarez et al., 2011, Forster et al., 2010, Armbruster et al., 2007)
                      Secondary FlyBase IDs
                      • FBgn0001106
                      • FBgn0261643
                      • FBgn0086717
                      • FBgn0031408
                      • FBgn0046217
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 51 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (85)