FB2026_02 , released June 18, 2026
Allele: Dmel\mAChR-AJF02725
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General Information
Symbol
Dmel\mAChR-AJF02725
Species
D. melanogaster
Name
FlyBase ID
FBal0242310
Feature type
allele
Associated gene
Dmel\mAChR-A
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02725}
Also Known As
TRiP.JF02725, UAS-mAChR-A RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02725}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02725
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of mAChR-AJF02725 under the control of Scer\GAL4GH298 leads to antennal lobe inhibitory local neurons showing abolished post-tetanic potentiation-induced potentiation, irrespective of membrane potential, as well as abolished nicotine-induced potentiation.

      (Rozenfeld et al., 2021)

      Expression of mAChR-AJF02725 under the control of Scer\GAL4ey-OK107, Scer\GAL4Mef2.247, or the combination of Scer\GAL4Mef2.247, Ecol\lexAGMR44E04, and Scer\GAL80IVS.WPRE.8xlexAop, but not Scer\GAL4c305a, and not the combination of Scer\GAL4Mef2.247, Ecol\lexAGMR45H04 and Scer\GAL80IVS.WPRE.8xlexAop, significantly reduces short-term aversive olfactory memory in adults, compared to controls; in the case of Scer\GAL4ey-OK107 there is no effect on naive odor or shock sensitivity and the memory defect is also seen when a Gal80[ts] transgene is used to restrict expression to the adult stage.

      (Bielopolski et al., 2019)

      Expression of mAChR-AJF02725 under the control of Scer\GAL4ey-OK107 significantly reduces the ability of larvae to form aversive associative olfactory memories in response to high salt concentration, with no defect in locomotion ability or olfactory acuity, compared to controls.

      (Silva et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      mAChR-AJF02725/Scer\GAL4GH298 fails to rescue mAChR-AKK

      (Rozenfeld et al., 2021)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      mAChR-AJF02725
      mAChRJF02725
      mAcR-60CJF02725
      mAcRJF02725
      Name Synonyms
      Secondary FlyBase IDs
        References (7)