FB2026_02 , released June 18, 2026
Allele: Dmel\Mkk4e01485
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General Information
Symbol
Dmel\Mkk4e01485
Species
D. melanogaster
Name
FlyBase ID
FBal0243039
Feature type
allele
Associated gene
Dmel\Mkk4
Associated Insertion(s)
PBac{RB}Mkk4e01485
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{RB}Mkk4e01485
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{RB}
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mkk4e01485 mutant clones in sensory neurons in adult wing do not display any defects in injury-induced axon degeneration (following an axotomy, the severed axons are cleared away normally).

        (Neukomm et al., 2017)

        Mkk4e01485 neuroblast clones in mushroom bodies show overextension of axons. Earlier born clones also show cell proliferation defects.

        Single cell Mkk4e01485 clones in mushroom bodies show a low frequency of axon breaks.

        (Rallis et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        Mkk4e01485 has abnormal neuroanatomy | somatic clone phenotype, enhanceable by hepr75

        (Rallis et al., 2010)
        Suppressed by
        Enhancer of
        Statement
        Reference

        Mkk4e01485 is an enhancer of abnormal neuroanatomy | somatic clone phenotype of hepr75

        (Rallis et al., 2010)
        NOT Suppressor of
        Other
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        Mkk4e01485 has Kenyon cell | somatic clone phenotype, enhanceable by hepr75

        (Rallis et al., 2010)

        Mkk4e01485 has axon | somatic clone phenotype, enhanceable by hepr75

        (Rallis et al., 2010)
        Suppressed by
        Enhancer of
        Statement
        Reference

        Mkk4e01485 is an enhancer of Kenyon cell | somatic clone phenotype of hepr75

        (Rallis et al., 2010)

        Mkk4e01485 is an enhancer of axon | somatic clone phenotype of hepr75

        (Rallis et al., 2010)
        NOT Suppressor of
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The axon degeneration in sensory neurons clones in the adult wing expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nSyb.PS can be suppressed by combination with Mkk4e01485.

        (Neukomm et al., 2017)

        28 day old flies containing hepr39 Mkk4e01485 double mutant neuroblast clones exhibit β-axon loss in the mushroom body.

        (Rallis et al., 2013)

        The axon overextension phenotype of Mkk4e01485 neuroblast clones in mushroom bodies is suppressed by expression of hepScer\UAS.cBa using Scer\GAL4ey-OK107.

        Single cell Mkk4e01485, hepr75 double mutant clones in mushroom bodies show a higher frequency of axon breaks than in clones of either single mutant.

        (Rallis et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Mkk4e01485 is rescued by Scer\GAL4ey-OK107/Mkk4UAS.YFP

        (Rallis et al., 2010)

        Df(3R)p13/Mkk4e01485 is rescued by Scer\GAL4Tub.PU/Mkk4UAS.YFP

        (Rallis et al., 2010)
        Comments

        Expression of Mkk4Scer\UAS.T:Avic\GFP-YFP using Scer\GAL4tub fully rescues the lethality associated with Mkk4e01485/Df(3R)p13.

        Expression of Mkk4Scer\UAS.T:Avic\GFP-YFP with Scer\GAL4ey-OK107 rescues the axonal phenotypes seen in Mkk4e01485 mushroom body clones.

        (Rallis et al., 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        Comments
        Comments

        FlyBase Curator comment: Authors refer to 'Mkk4[e01458]' but this must be a typo for Mkk4e01485.

        (Rallis et al., 2010)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        MAPKK4e01485
        (Guichard et al., 2006)
        Mkk4e01485
        (Jin et al., 2020)
        mkk4e01485
        (Hsu et al., 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)