FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mkk4G587
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General Information
Symbol
Dmel\Mkk4G587
Species
D. melanogaster
Name
FlyBase ID
FBal0265745
Feature type
allele
Associated gene
Dmel\Mkk4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Geuking et al., 2009)
Progenitor genotype
Cytology
Description

Amino acid replacement: W329term.

(Geuking et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,649,307..8,649,307 [-]
Nucleotide change:

G8649307A

Reported nucleotide change:

G?A

Amino acid change:

W329term | Mkk4-PA; W329term | Mkk4-PB; W329term | Mkk4-PC

Reported amino acid change:

W329term

Comment:

TGG to TAG substitution reported.

(Geuking et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mkk4G587/Mkk4G414 mutant larvae do not exhibit a melanotic phenotype in the posterior hindgut either under normal food conditions or when raised on food containing 0.1M or 0.2M NaCl.

      (Seisenbacher et al., 2011)

      Mkk4G587/Df(3R)Exel6149 flies are viable and do not show any obvious morphological defects.

      (Geuking et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mkk4G587/Mkk4G414 is a suppressor | partially of melanotic mass phenotype | larval stage | nutrition conditional phenotype of MAPk-Ak2Δ43

      (Seisenbacher et al., 2011)

      Mkk4[+]/Mkk4G587 is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)

      Mkk4[+]/Mkk4G587 is a suppressor of visible | adult stage phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      Mkk4G673/Mkk4G587 is a non-suppressor of abnormal size | adult stage phenotype of Scer\GAL4GMR.PF, hepCA.UAS

      (Geuking et al., 2009)

      Mkk4G673/Mkk4G587 is a non-suppressor of visible | adult stage phenotype of Scer\GAL4GMR.PF, hepCA.UAS

      (Geuking et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Mkk4G587/Mkk4G414 is a suppressor | partially of embryonic/larval hindgut | posterior | larval stage | nutrition conditional phenotype of MAPk-Ak2Δ43

      (Seisenbacher et al., 2011)

      Mkk4[+]/Mkk4G587 is a suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      Mkk4G673/Mkk4G587 is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, hepCA.UAS

      (Geuking et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mkk4G587/Mkk4G414 partially suppresses the "black dot" phenotype seen in the hindgut of MAPk-Ak2Δ43 larvae raised on either 0.1M or 0.2M NaCl.

      (Seisenbacher et al., 2011)

      Mkk4G587/+ suppresses the small eye phenotype seen when egrScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PF.

      Mkk4G587/Mkk4G673 does not suppress the small eye phenotype seen when hepCA.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.

      (Geuking et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MKK4G587
      (Seisenbacher et al., 2011)
      Mkk4G587
      (Jin et al., 2020, Geuking et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)