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General Information
Symbol
Hsap\APPArctic.Aβ42.UAS.Tag:SS(rPENK)
Species
H. sapiens
Name
FlyBase ID
FBal0243229
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
AΒ42Arc
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an Aβ42 peptide carrying the Arctic mutation (amino acid replacement E22G). The protein is tagged with the Tag:SS(rPENK) signal peptide.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
This allele represents a human variant implicated in disease.

This construct carries the amyloid Aβ42 peptide; variant described relative to the full-length protein and in terms of the Aβ42 peptide.

APP:p.Glu693Gly
Variants Synonym(s)
APP(Aβ42 peptide):p.Glu22Gly
External database links
Comments concerning this variant
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\APPAβ1-42.Scer\UAS.Arc in the central clock neurons under the control of Scer\GAL4P2.4.Pdf elevates the levels of fat body triglycerides compared to controls. Circadian behavior appears normal. These mutants do not consume more food over a 24hr period compared to controls.

Expression of Hsap\APPAβ1-42.Scer\UAS.Arc in the eye under the control of Scer\GAL4GMR.PF causes degeneration.

Expression of Hsap\APPAβ1-42.Scer\UAS.Arc driven by Scer\GAL4elav-C155 results in neurodegeneration, locomotor dysfunction and decreased adult lifespan. 5 and 10 day old mutant flies also manifest 1 hour memory defects.

Scer\GAL4elav-C155- or Scer\GAL4ey-OK107-driven expression of Hsap\APPAβ1-42.Scer\UAS.Arc results in neuropil degeneration in flies 79 days after eclosion.

Calyxes in the adult mushroom body expressing Scer\GAL4ey-OK107-driven Hsap\APPAβ1-42.Scer\UAS.Arc start to degenerate 79 days after eclosion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of lokScer\UAS.cPa does not enhance the eye degeneration phenotype seen when Hsap\APPAβ1-42.Scer\UAS.Arc is expressed under the control of Scer\GAL4GMR.PF.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hsap\APPArctic.Aβ42.Scer\UAS.T:Rnor\SS-PENK
Hsap\APPArctic.Aβ42.UAS.Tag:SS(rPENK)
Hsap\APPAβ1-42.Scer\UAS.Arc
Name Synonyms
Secondary FlyBase IDs
    References (5)