FlyBase Allele Report: Dmel\sea[Δ24]

General Information

Symbol

Dmel\sea^Δ24

Species

D. melanogaster

Name

FlyBase ID

FBal0243639

Feature type

allele

Associated gene

Dmel\sea

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Morciano et al., 2009)

Mutagen

Delta2-3 transposase

(Morciano et al., 2009)

Progenitor genotype

P{EP}sea^EP3364

(Morciano et al., 2009)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion.

(Morciano et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of mitochondrial metabolism disease

CEA

(Gokhale et al., 2019)

model of combined D-2- and L-2-hydroxyglutaric aciduria

CEA

(Li et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of combined D-2- and L-2-hydroxyglutaric aciduria

is ameliorated by Pfk^HMS01324

(Li et al., 2018)

is ameliorated by Ldh^HMS00039

(Li et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

FlyBase curator comment: The disease model used a hemizygous genotype of sea^Δ24/Df.

(Li et al., 2018)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Morciano et al., 2009)

abnormal mitotic cell cycle (with Df(3R)Mx-1)

(Morciano et al., 2009)

abnormal mitotic cell cycle (with sea^EP3364)

(Morciano et al., 2009)

lethal

(Morciano et al., 2009)

Phenotype Manifest In

condensed chromosome

(Morciano et al., 2009)

condensed chromosome (with Df(3R)Mx-1)

(Morciano et al., 2009)

condensed chromosome (with sea^EP3364)

(Morciano et al., 2009)

larval neuroblast

(Morciano et al., 2009)

larval neuroblast (with Df(3R)Mx-1)

(Morciano et al., 2009)

larval neuroblast (with sea^EP3364)

(Morciano et al., 2009)

Detailed Description

Statement

Reference

Brain neuroblasts of homozygous and sea^Δ24/Df(3R)Mx-1 larvae show defects in mitosis, with a high frequency of chromosome breaks. The mitotic index of the mutant cells is reduced approximately 3-fold in sea^Δ24/Df(3R)Mx-1 larvae.

Brain neuroblasts of sea^Δ24/sea^EP3364 larvae show defects in mitosis, with a high frequency of chromosome breaks. Mutant cells with highly fragmented nuclei containing chromosome "splinters" are also seen.

(Morciano et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

sea^Δ24 mus304^D4 double mutants show a 2.5 fold increase in the mitotic index of larval brain neuroblasts compared to sea^Δ24 single mutants.

(Morciano et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sea^Δ24

(Gokhale et al., 2019, Li et al., 2018, Morciano et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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