FlyBase Allele Report: Dmel\Ldh[HMS00039]

General Information

Symbol

Dmel\Ldh^HMS00039

Species

D. melanogaster

Name

FlyBase ID

FBal0257081

Feature type

allele

Associated gene

Dmel\Ldh

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00039}

Also Known As

Ldh RNAi, UAS-LDH-RNAi, LdhRNAi, UAS-Ldh^RNAi, HMS00039

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00039}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00039

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates combined D-2- and L-2-hydroxyglutaric aciduria

modeled by sea^Δ24

(Li et al., 2018)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Niccoli et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased efficacy of long-term memory | adult stage, with Scer\GAL4^GMR14H06

(Raun et al., 2025)

long lived, with Scer\GAL4^elav.PU

(Long et al., 2020)

long lived, with Scer\GAL4^repo.PU

(Long et al., 2020)

long lived, with Scer\GAL4^tim.PE

(Long et al., 2020)

Phenotype Manifest In

vacuole | adult stage | decreased number, with Scer\GAL4^elav.PU

(Long et al., 2020)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Ldh^HMS00039, Scer\GAL4^repo is a suppressor | partially of abnormal wound healing | larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^repo

(Li et al., 2020)

Ldh^HMS00039, Scer\GAL4^repo is a suppressor | partially of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ldh^HMS00039, Scer\GAL4^repo is a suppressor | partially of larval multidendritic class IV neuron phenotype of Myc^UAS.cZa, Scer\GAL4^repo

(Li et al., 2020)

Ldh^HMS00039, Scer\GAL4^repo is a suppressor | partially of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Ldh^HMS00039/Scer\GAL4^54C is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Ldh^HMS00039/Scer\GAL4^54C is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Ldh^HMS00039/Scer\GAL4^elav.PLu is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Ldh^HMS00039/Scer\GAL4^elav.PLu is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Ldh^HMS00039, Scer\GAL4^nSyb.PS is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of SREBP^UAS.cKa, Scer\GAL4^nSyb.PS

(Liu et al., 2017)

Ldh^HMS00039, Scer\GAL4^nSyb.PS is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of SREBP^UAS.cKa, Scer\GAL4^nSyb.PS

(Liu et al., 2017)

Ldh^HMS00039, Scer\GAL4^nSyb.PS is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of Scer\GAL4^nSyb.PS, bsk^UAS.cBa

(Liu et al., 2017)

Ldh^HMS00039, Scer\GAL4^nSyb.PS is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of Scer\GAL4^nSyb.PS, bsk^UAS.cBa

(Liu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is ameliorated by the expression of Ldh^HMS00039 when driven by either Scer\GAL4^54C or Scer\GAL4^elav.PLu.

The accumulation of lipid droplets in the retinal glia of adult flies expressing either SREBP^UAS.cKa or bsk^Scer\UAS.cBa under the control of Scer\GAL4^nSyb.PS is significantly suppressed by co-expression of Ldh^HMS00039.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33640