FlyBase Gene Report: Dmel\sea

General Information

Symbol

Dmel\sea

Species

D. melanogaster

Name

scheggia

Annotation Symbol

CG6782

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037912

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

scheggia (sea) encodes a carrier protein of the inner mitochondrial membrane that plays a central role in fatty acid and sterol biosynthesis. It catalyses an electroneutral exchange of citrate for another tricarboxylate, a dicarboxylate (L-malate), or phosphoenolpyruvate across the inner mitochondrial membrane. The product of sea is also required to prevent chromosome breaks. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DmCIC

Key Links

Genomic Location

Cytogenetic map

86E10-86E10

Sequence location

3R:11,559,896..11,567,054 [-]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:11559896..11567054

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables citrate secondary active transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000640552

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in citrate transport

inferred from direct assay

(Carrisi et al., 2008)

involved_in mitochondrial citrate transmembrane transport

inferred from mutant phenotype

(Morciano et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitochondrial citrate transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000640552

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in mitochondrion

inferred from direct assay

(Morciano et al., 2009)

located_in Nebenkern

inferred from direct assay

(Morciano et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN002909487

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS -: The solute carrier family 25 (SLC25) or mitochondrial carrier family (MCF) members shuttle metabolites, nucleotides and cofactors across the inner mitochondrial membrane. (Adapted from FBrf0212481, FBrf0212949 and PMID:23266187).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sea for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KSQ0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region; overlap >20aa.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sea-RA

FBtr0100461

NM_001032007

1318

317

sea-RC

FBtr0100462

NM_001032006

1347

317

sea-RD

FBtr0100464

NM_001032005

1660

317

sea-RE

FBtr0100465

NM_001032004

1444

317

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

sea-PA

FBpp0099888

34.1

317

9.91

FBpp0099889

34.1

317

9.91

FBpp0099890

34.1

317

9.91

FBpp0099892

34.1

317

9.91

Q7KSQ0

NP_001027175

AAN13510

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

317 aa isoforms: sea-PA, sea-PC, sea-PD, sea-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KSQ0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sea using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sea_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.24

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval neuroblast | punctate

(Morciano et al., 2009)

adult stage | male & spermatogenesis

Nebenkern

(Morciano et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

organism

• mitochondrion

(Morciano et al., 2009)

Additional Descriptive Data

sea immunoreactivity has a punctate distribution in the cytosol of larval neuroblasts, where it colocalizes with ScsbetaA protein. sea also colocalizes with the Nebenkern.

(Morciano et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrion

inferred from direct assay

(Morciano et al., 2009)

located_in Nebenkern

inferred from direct assay

(Morciano et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sea in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sea

View exonic expression by tissue for Dmel\sea

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772221/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037912

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037912

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037912

Flygut - An atlas of the Drosophila adult midgut

FBgn0037912

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sea

Transgenic constructs containing regulatory region of sea

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Mx-1

(Morciano et al., 2009)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

sea^Δ24

viable

sea^BG02200

Sterility

Allele

male fertile, with Scer\GAL4^bam.PU

Other Phenotypes

Allele

abnormal mitotic cell cycle

abnormal mitotic cell cycle (with Df(3R)Mx-1)

abnormal mitotic cell cycle (with sea^EP3364)

sea^Δ24

abnormal mitotic cell cycle (with sea^Δ24)

sea^EP3364

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

sea^GD17700

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^elav-C155

sea^GD17700

abnormal size | adult stage, with Scer\GAL4^eya.enh1+E+2

sea^HMS01163

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

sea^HMS01163

Phenotype manifest in

Allele

chromosome | larval stage

sea^EP3364

condensed chromosome

condensed chromosome (with Df(3R)Mx-1)

condensed chromosome (with sea^EP3364)

sea^Δ24

condensed chromosome (with sea^Δ24)

sea^EP3364

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

sea^GD17700

eye, with Scer\GAL4^eya.enh1+E+2

sea^HMS01163

larval neuroblast

larval neuroblast (with Df(3R)Mx-1)

larval neuroblast (with sea^EP3364)

sea^Δ24

larval neuroblast (with sea^Δ24)

sea^EP3364

larval neuroblast | larval stage (with Df(2R)Exel7138)

sea^EP3364

NMJ bouton | increased number | third instar larval stage, with Scer\GAL4^elav-C155

sea^GD17700

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (43)

Hsap\SLC25A1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Slc25a1

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Slc25a45

1 of 14

Rnor\Slc25a47

1 of 14

Rnor\Ucp2

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\Slc25a1

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (23)

Xtro\slc25a1

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (38)

Drer\slc25a1a

12 of 14

Yes

Drer\slc25a1b

11 of 14

Yes

Drer\si:dkey-178e17.1

10 of 14

Yes

Drer\mtch2

1 of 14

Drer\si:dkey-150i13.2

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (33)

Cele\K11H3.3

13 of 14

Yes

Cele\Y37B11A.3

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (28)

Agam\ADT1_ANOGA

1 of 12

Yes

Agam\ADT2_ANOGA

1 of 12

Yes

Agam\AgaP_AGAP000097

1 of 12

Yes

Agam\AgaP_AGAP000958

1 of 12

Yes

Agam\AgaP_AGAP001297

1 of 12

Yes

Agam\AgaP_AGAP002280

1 of 12

Yes

Agam\AgaP_AGAP002939

1 of 12

Yes

Agam\AgaP_AGAP003073

1 of 12

Yes

Agam\AgaP_AGAP003074

1 of 12

Yes

Agam\AgaP_AGAP003208

1 of 12

Yes

Agam\AgaP_AGAP003536

1 of 12

Yes

Agam\AgaP_AGAP003586

1 of 12

Yes

Agam\AgaP_AGAP004179

1 of 12

Yes

Agam\AgaP_AGAP005113

1 of 12

Yes

Agam\AgaP_AGAP006104

1 of 12

Yes

Agam\AgaP_AGAP006508

1 of 12

Yes

Agam\AgaP_AGAP006806

1 of 12

Yes

Agam\AgaP_AGAP006963

1 of 12

Yes

Agam\AgaP_AGAP007520

1 of 12

Yes

Agam\AgaP_AGAP007653

1 of 12

Yes

Agam\AgaP_AGAP009128

1 of 12

Yes

Agam\AgaP_AGAP009333

1 of 12

Yes

Agam\AgaP_AGAP009603

1 of 12

Yes

Agam\AgaP_AGAP010293

1 of 12

Yes

Agam\AgaP_AGAP011676

1 of 12

Yes

Agam\AgaP_AGAP011839

1 of 12

Yes

Agam\AgaP_AGAP012097

1 of 12

Yes

Agam\AgaP_AGAP013333

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (43)

Atha\mSFC1

6 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (26)

Scer\CTP1

12 of 13

Yes

Scer\MRX20

3 of 13

Yes

Scer\SFC1

3 of 13

Yes

Scer\YHM2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (10)

Spom\SPAC19G12.05

12 of 12

Yes

Spom\SPBC83.13

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:sea. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (46)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

GC1

2 of 13

GC2

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

sea^Δ24

model of mitochondrial metabolism disease

CEA

(Gokhale et al., 2019)

model of combined D-2- and L-2-hydroxyglutaric aciduria

CEA

(Li et al., 2018)

sea^RNAi.UAS.cUa

model of mitochondrial metabolism disease

CEA

(Gokhale et al., 2019)

sea^GD17700

model of DiGeorge syndrome

CEA

(Gokhale et al., 2021)

model of combined D-2- and L-2-hydroxyglutaric aciduria

CEA

(Gokhale et al., 2021)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC25A1; solute carrier family 25 member 1

model of combined D-2- and L-2-hydroxyglutaric aciduria

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

sea^Δ24

model of combined D-2- and L-2-hydroxyglutaric aciduria

is ameliorated by Ldh^HMS00039

(Li et al., 2018)

is ameliorated by Pfk^HMS01324

(Li et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC25A1; solute carrier family 25 member 1

11 of 14

190315

combined D-2- and L-2-hydroxyglutaric aciduria

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

sea - ksr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

sea

enhanceable

Acly

(Morciano et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acly

enhanceable

sea

(Morciano et al., 2019)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037912

MIST (protein-protein) - An integrated Molecular Interaction Database

3772221

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Organic anion transporters

Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2002-2003)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

86E10-86E10

Sequence location

3R:11,559,896..11,567,054 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86E10-86E10

Limits computationally determined from genome sequence between P{PZ}tho¹&P{PZ}l(3)04629⁰⁵²⁷⁵ and P{EP}Lk6^EP886

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-48.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

79224

y¹ w^67c23; P{UAS-sea.FLAG.HA}attP1

33976

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00936}attP2

34685

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01163}attP2

50808

y¹ w^*; P{PTT-GA}fabp^CA06960 sea^CA06960

17118

w¹¹¹⁸; P{EP}sea^EP3364 fabp^EP3364/TM6B, Tb¹

15579

y¹ w^*; P{EPgy2}fabp^EY02678a sea^EY02678a P{EPgy2}Mrp4^EY02678b/TM3, Sb¹

Korea

11589

P{EP}sea^G15375

Kyoto

123217

w¹¹¹⁸; P{RS3}sea^CB-0520-3

123539

w¹¹¹⁸; P{RS3}sea^CB-5268-3

NIG-Fly

HMS01163

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01163}attP2

VDRC

v109169

P{KK116001}VIE-260B

v50714

w¹¹¹⁸ P{GD17700}v50714

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (193)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD46175

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037912

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037912

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Morciano et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

(Hansen et al., 2009)

Relationship to Other Genes

Source for database merge of

Additional comments

Dicistronic annotation CG31305 split out into separate annotations for each open reading frame, CG6783 and CG6782 in release 4.2 of the genome annotation.

(FlyBase Genome Annotators, 2005)

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG6783 and sea.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: sea CG6782

(Morciano et al., 2009)

Nomenclature comments

Etymology

The gene is named after the chromosome splinter ("scheggia" in Italian) phenotype of mutants.

(Morciano et al., 2009)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG31305

(Hansen et al., 2009, Quinones-Coello, 2007, Dionne et al., 2006, Burgler and Macdonald, 2005, Giot et al., 2003)

CG6782

(Curcio et al., 2020, Çiçek et al., 2016, Nguyen et al., 2016, Jaspers et al., 2012, Cammarato et al., 2011, Featherstone, 2011, Knowles-Barley et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Carrisi et al., 2008, Quinones-Coello, 2007, Zhang et al., 2007, Beller et al., 2006, Sambandan et al., 2006)

DmCIC

(Curcio et al., 2020, Niwa and Enya, 2011, Carrisi et al., 2008)

SLC25A1

(Morciano et al., 2009)

Sea

(Pang et al., 2023, Cogni et al., 2015)

anon-WO0140519.12

l(3)EP3364

(Morciano et al., 2009)

sea

(De Groef et al., 2024, François et al., 2023, Curcio et al., 2020, Maurer et al., 2020, Gokhale et al., 2019, Morciano et al., 2019, Yuan et al., 2019, Zhang et al., 2016, Grice et al., 2015, Van Bortle et al., 2015, Clark et al., 2013, Kwon et al., 2013, Friedman et al., 2011, Morciano et al., 2009)

sea^Δ24

(Gokhale et al., 2019)

Name Synonyms

Scheggia

(Morciano et al., 2019)

scheggia

(Curcio et al., 2020, Morciano et al., 2009)

Secondary FlyBase IDs

FBgn0044763
FBgn0051305
FBtr0089774
FBpp0088715
FBtr0089775
FBpp0088716
FBtr0089776
FBpp0088717
FBtr0089777
FBpp0088718
FBtr0089778
FBpp0088719
FBtr0089779
FBpp0088720
FBtr0089780
FBpp0088721

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3772221

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KSQ0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7KSQ0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KSQ0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772221/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037912

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037912

FlyMine - An integrated database for Drosophila genomics

FBgn0037912

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6782

MARRVEL_MODEL - MARRVEL (model organism gene)

3772221

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037912

DroID - A comprehensive database of gene and protein interactions.

FBgn0037912

DRSC - Results frm RNAi screens

FBgn0037912

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sea_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037912

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037912

Flygut - An atlas of the Drosophila adult midgut

FBgn0037912

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037912

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015070

MIST (protein-protein) - An integrated Molecular Interaction Database

3772221

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Organic anion transporters

References (69)

The following external sites may use different assemblies or annotations than FlyBase.

-0.24

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