FlyBase Gene Report: Dmel\SCaMC

General Information

Symbol

Dmel\SCaMC

Species

D. melanogaster

Name

Short Calcium-binding Mitochondrial Carrier

Annotation Symbol

CG32103

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052103

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Short Calcium-binding Mitochondrial Carrier (SCaMC) encodes a mitochondrial carrier family protein with calcium-binding motifs. SCaMC transcripts are strongly detected in the corpora allata, suggesting its potential role in juvenile hormone biosynthesis. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

69B4-69B5

Sequence location

3L:12,402,295..12,414,842 [-]

Recombination map

3-38

RefSeq locus

NT_037436 REGION:12402295..12414842

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ATP transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000639825

(GO Reference Genome Project, 2011-)

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in ADP transport

inferred from biological aspect of ancestor with PANTHER:PTN000641656

(GO Reference Genome Project, 2011-)

involved_in ATP transport

inferred from biological aspect of ancestor with PANTHER:PTN000641656

(GO Reference Genome Project, 2011-)

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR002067

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from electronic annotation with InterPro:IPR002167

(InterPro Project Members, 2004-)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000639825

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS

Protein Family (UniProt)

Belongs to the mitochondrial carrier (TC 2.A.29) family. (Q0E8F2)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS -: The solute carrier family 25 (SLC25) or mitochondrial carrier family (MCF) members shuttle metabolites, nucleotides and cofactors across the inner mitochondrial membrane. (Adapted from FBrf0212481, FBrf0212949 and PMID:23266187).

Protein Function (UniProtKB)

Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane (By similarity). Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity (By similarity). Could also have a broader specificity for adenyl nucleotides (By similarity). By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (By similarity). Acts downstream of Ca(2+)-permeable cation channel Pkd2/Amo and it is likely that Pkd2-mediated Ca(2+) signaling activates SCaMC antiporter activity (By similarity). Required to ensure that sperm which have been transferred to the uterus are able to reach the seminal receptacle, a female sperm storage organ (PubMed:30080851).

(UniProt, Q0E8F2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SCaMC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0E8F2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SCaMC-RB

FBtr0075982

NM_168498

2622

583

SCaMC-RC

FBtr0075983

NM_168499

2060

363

SCaMC-RD

FBtr0332089

NM_001274831

1603

350

SCaMC-RE

FBtr0332090

NM_206345

3836

583

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SCaMC-PB

FBpp0075714

65.4

583

6.52

FBpp0075715

40.7

363

9.57

FBpp0304399

39.0

350

9.00

FBpp0304400

65.4

583

6.52

Q0E8F2

NP_996067

AAS65015

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

583 aa isoforms: SCaMC-PB, SCaMC-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The regulatory N-terminal domain/NTD binds calcium in the mitochondrial intermembrane space and regulates the antiporter activity of the transmembrane domain/TMD. In absence of calcium, the apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, inhibiting the transporter activity. Binding of calcium leads to a major conformational change and abolishes the interaction with the transmembrane domain and the inhibition of the transporter activity.

The C-terminal mitochondrial carrier domain/transmembrane domain/TMD bears the transmembrane transporter activity.

Linker region/H9 could directly block the transport of substrates across the transporter.

(UniProt, Q0E8F2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SCaMC using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.39

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

(Arbeitman et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval corpus allatum

(Niwa and Enya, 2011)

third instar larval stage

embryonic/larval corpus allatum

(Niwa and Enya, 2011)

embryonic/larval fat body

(Niwa and Enya, 2011)

adult stage | male

testis

(Niwa and Enya, 2011)

adult stage | female

ovary

(Niwa and Enya, 2011)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

(Arbeitman et al., 2004)

Additional Descriptive Data

All three isoforms of SCaMC are expressed in the corpus allatum in the ring gland in larvae as well as in most larval tissues. Isoform-specific expression patterns are observed. SCaMC-RC is expressed at a 10X higher level in intestines and fat body than in the corpus allatum. All isoforms are expressed in adult testes and ovaries.

(Niwa and Enya, 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Ptth-GAL4.N}SCaMC^GAL4

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

embryonic/larval corpus allatum

(Niwa and Enya, 2011)

second instar larval stage

embryonic/larval corpus allatum

(Niwa and Enya, 2011)

third instar larval stage

embryonic/larval corpus allatum

(Niwa and Enya, 2011)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SCaMC in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SCaMC

View exonic expression by tissue for Dmel\SCaMC

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39415/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052103

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052103

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052103

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32103

Flygut - An atlas of the Drosophila adult midgut

FBgn0052103

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SCaMC

Transgenic constructs containing regulatory region of SCaMC

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SCaMC^GD14864

viable, with Scer\GAL4^Mef2.PR

SCaMC^GD14864

viable, with Scer\GAL4^pnr-MD237

SCaMC^GD14864

viable, with Scer\GAL4^tin.CΔ4

SCaMC^GD14864

Sterility

Allele

male semi-fertile, with SCaMC^{EF.βTub85D.Tag:V5}

SCaMC^Z3-2147

male semi-fertile, with SCaMC^Z3-2147

male semi-fertile, with SCaMC^{Δ1-268.βTub85D.Tag:V5}

SCaMC^Z3-2147

male sterile (with Df(3L)BSC380)

SCaMC^Z3-2147

male sterile | recessive

SCaMC^Z3-2147

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (51)

Hsap\SLC25A25

13 of 14

Yes

Hsap\SLC25A23

11 of 14

Yes

Hsap\SLC25A24

11 of 14

Yes

Hsap\SLC25A41

6 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Slc25a25

13 of 14

Yes

Rnor\Slc25a23

11 of 14

Yes

Rnor\Slc25a24

11 of 14

Yes

Rnor\Slc25a54

9 of 14

Yes

Rnor\Slc25a41

6 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (22)

Mmus\Slc25a25

12 of 14

Yes

Mmus\Slc25a23

11 of 14

Yes

Mmus\Slc25a24

11 of 14

Yes

Mmus\Slc25a54

8 of 14

Yes

Mmus\Slc25a41

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (31)

Xtro\slc25a25

11 of 13

Yes

Xtro\slc25a24

9 of 13

Yes

Xtro\slc25a23

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (30)

Drer\slc25a25b

13 of 14

Yes

Drer\slc25a25a

12 of 14

Yes

Drer\slc25a23a

11 of 14

Yes

Drer\slc25a23b

11 of 14

Yes

Drer\slc25a24

11 of 14

Yes

Drer\slc25a24l

6 of 14

Yes

Drer\LOC566378

1 of 14

Drer\si:dkey-251i10.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (25)

Cele\F17E5.2

14 of 14

Yes

Cele\F55A11.4

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (23)

Agam\AgaP_AGAP006508

11 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (42)

Atha\APC3

12 of 13

Yes

Atha\APC1

11 of 13

Yes

Atha\APC2

11 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (23)

Scer\SAL1

7 of 13

Yes

5 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (9)

Spom\SPBC12D12.05c

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SCaMC. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (48)

5 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

GC1

2 of 13

GC2

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

sea

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Pef

1 of 13

Ucp4A

1 of 13

Ucp4B

1 of 13

Ucp4C

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC25A25; solute carrier family 25 member 25

13 of 14

608745

SLC25A23; solute carrier family 25 member 23

11 of 14

608746

SLC25A24; solute carrier family 25 member 24

11 of 14

608744

FONTAINE PROGEROID SYNDROME; FPS

SLC25A41; solute carrier family 25 member 41

6 of 14

610822

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

SCaMC

Hsap\SLC25A5

(Hofherr et al., 2018)

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ZnT49B

suppressible

SCaMC

(Ge et al., 2024)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64766

DroID - A comprehensive database of gene and protein interactions.

FBgn0052103

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-38

Cytogenetic map

69B4-69B5

Sequence location

3L:12,402,295..12,414,842 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69B4-69B5

Limits computationally determined from genome sequence between P{PZ}l(3)05088⁰⁵⁰⁸⁸ and P{PZ}l(3)06924⁰⁶⁹²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-38

(FlyBase, 2016)

3-31.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

15819

y¹ w^67c23; P{EPgy2}SCaMC^EY06230

83987

y¹ sc^* v¹ sev²¹; P{TKO.GS04084}attP40

67772

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05666}attP40

Kyoto

126070

w¹¹¹⁸; P{RS5}SCaMC^5-SZ-3455

104710

w^*; P{GawB}SCaMC^NP4605 / TM3, Sb¹ Ser¹

VDRC

v108078

P{KK100089}VIE-260B

v29439

w¹¹¹⁸; P{GD14864}v29439

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (121)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052103

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052103

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG4392 CG18022

(FlyBase, 1996-)

Additional comments

Annotations CG18022, CG4392 merged as CG32103 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG4392 CG18022 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: SCaMC CG32103

(Hofherr et al., 2018)

Nomenclature comments

Etymology

The gene is named 'SCaMC' based on function and orthology.

(Hofherr et al., 2018)

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG18022

CG32103

(Curcio et al., 2020, Signor, 2020, Hofherr et al., 2018, Rohde et al., 2018, Transgenic RNAi Project members, 2017-, Cui et al., 2016, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Cammarato et al., 2011, Niwa and Enya, 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Bushati et al., 2008)

CG4392

(Arbeitman et al., 2004, Mount, 2001.8.14)

SCaMC

(Curcio et al., 2020, Hofherr et al., 2018)

Name Synonyms

Short Calcium-binding Mitochondrial Carrier

Secondary FlyBase IDs

FBgn0036283
FBgn0036284

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39415

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0E8F2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q0E8F2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0E8F2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39415/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052103

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052103

FlyMine - An integrated database for Drosophila genomics

FBgn0052103

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32103

MARRVEL_MODEL - MARRVEL (model organism gene)

39415

Linkouts

BioGRID - A database of protein and genetic interactions.

64766

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052103

DroID - A comprehensive database of gene and protein interactions.

FBgn0052103

DRSC - Results frm RNAi screens

FBgn0052103

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052103

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052103

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32103

Flygut - An atlas of the Drosophila adult midgut

FBgn0052103

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006460

References (51)

The following external sites may use different assemblies or annotations than FlyBase.

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