FlyBase Allele Report: Dmel\Tl[UASp.Venus]

General Information

Symbol

Dmel\Tl^UASp.Venus

Species

D. melanogaster

Name

FlyBase ID

FBal0243765

Feature type

allele

Associated gene

Dmel\Tl

Associated Insertion(s)

Carried in Construct

P{UASp-Tl.Venus}

Key Links

Transgenic product class

cDNA

(Mavrakis et al., 2009)

wild_type

(Mavrakis et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Mavrakis et al., 2009)

wild_type

(Mavrakis et al., 2009)

Mutagen

in vitro construct

(Mavrakis et al., 2009)

Progenitor genotype

Carried in construct

P{UASp-Tl.Venus}

Cytology

Description

UASp regulatory sequences drive expression of a full-length Tl cDNA tagged with C-terminal Venus.

(Mavrakis et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Tagged with

Venus

yellow fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by dlg1^A40.2

(Parisi et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Tl^UASp.Venus under the control of Scer\GAL4^ppl.PP does not have an obvious effect on the growth, patterning and apoptosis levels (cleaved caspase 3 immunostaining) in the wing disc, which is in agreement with the normal adult wing mosphology, as compared to controls

(Parisi et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Suppressor of

Statement

Reference

Tl^UASp.Venus/Scer\GAL4^ppl.PP is a suppressor | partially of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus/Scer\GAL4^Cg.PA is a suppressor | partially of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

NOT Suppressor of

Statement

Reference

Tl^UASp.Venus/Scer\GAL4^Hml.Δ is a non-suppressor of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is a non-suppressor of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Other

Statement

Reference

Scer\GAL4^ppl.PP, Tl^UASp.Venus, dlg1^A40.2 has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2 has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2, egr^KK103432 has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Suppressor of

Statement

Reference

Tl^UASp.Venus/Scer\GAL4^ppl.PP is a suppressor | partially of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus/Scer\GAL4^Cg.PA is a suppressor | partially of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

NOT Suppressor of

Statement

Reference

Tl^UASp.Venus/Scer\GAL4^Hml.Δ is a non-suppressor of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Tl^UASp.Venus, Scer\GAL4^Cg.PA, egr^KK103432 is a non-suppressor of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Other

Statement

Reference

Scer\GAL4^ppl.PP, Tl^UASp.Venus, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The apoptosis observed in dlg1^A40.2 mutant wing disc tumors is significantly increased by the expression of Tl^UASp.Venus under the control of either Scer\GAL4^ppl.PP or Scer\GAL4^Cg.PA but is virtually abrogated by the co-expression of Tl^UASp.Venus and egr^KK103432 under the control of Scer\GAL4^Cg.PA.

(Parisi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

30898

w^*; P{UASp-Tl.Venus}4

30899

w^*; P{UASp-Tl.Venus}1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tl^{Scer\UAS.P\T.T:Avic\GFP-YFP.Venus}

Tl^UASp.Venus

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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