FlyBase Allele Report: Dmel\Tollo[1]

General Information

Symbol

Dmel\Tollo¹

Species

D. melanogaster

Name

FlyBase ID

FBal0244016

Feature type

allele

Associated gene

Dmel\Tollo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Ayyar et al., 2007, Ayyar et al., 2007)

Progenitor genotype

P{GawB}MD806

(Ayyar et al., 2007, Ayyar et al., 2007)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion of 2247bp which includes part of the Tollo gene.

(Ayyar et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Akhouayri et al., 2011, Ayyar et al., 2007)

visible | cold sensitive

(Ayyar et al., 2007)

visible | dominant

(Ayyar et al., 2007)

Phenotype Manifest In

macrochaeta | ectopic | cold sensitive

(Ayyar et al., 2007)

mesonotum | cold sensitive

(Ayyar et al., 2007)

Detailed Description

Statement

Reference

No obvious developmental defects are seen in Tollo¹ mutants and phenotypically normal pharate adults are produced.

(Akhouayri et al., 2011)

Homozygous flies show ectopic macrochaetae in 63% of heminota analysed at 18[o]C.

Heterozygotes show ectopic bristles in 10% of heminota at 18[o]C.

(Ayyar et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tollo¹ has visible | dominant phenotype, enhanceable by Dredd[+]/Dredd^EP1412

(Ayyar et al., 2007)

Tollo¹ has visible | dominant phenotype, enhanceable by Rel^E20/Rel[+]

(Ayyar et al., 2007)

Enhancer of

Statement

Reference

Tollo¹/Tollo[+] is an enhancer of visible | dominant phenotype of Rel^E20

(Ayyar et al., 2007)

Tollo¹/Tollo[+] is an enhancer of visible | dominant phenotype of Dredd^EP1412

(Ayyar et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Tollo¹ has mesonotum phenotype, enhanceable by Dredd[+]/Dredd^EP1412

(Ayyar et al., 2007)

Tollo¹ has macrochaeta | ectopic phenotype, enhanceable by Dredd[+]/Dredd^EP1412

(Ayyar et al., 2007)

Tollo¹ has mesonotum phenotype, enhanceable by Rel^E20/Rel[+]

(Ayyar et al., 2007)

Tollo¹ has macrochaeta | ectopic phenotype, enhanceable by Rel^E20/Rel[+]

(Ayyar et al., 2007)

Enhancer of

Statement

Reference

Tollo¹/Tollo[+] is an enhancer of mesonotum phenotype of Rel^E20

(Ayyar et al., 2007)

Tollo¹/Tollo[+] is an enhancer of macrochaeta | ectopic phenotype of Dredd^EP1412

(Ayyar et al., 2007)

Tollo¹/Tollo[+] is an enhancer of macrochaeta | ectopic phenotype of Rel^E20

(Ayyar et al., 2007)

Tollo¹/Tollo[+] is an enhancer of mesonotum phenotype of Dredd^EP1412

(Ayyar et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Dredd^EP1412/+ Tollo¹/+ double heterozygotes show ectopic bristles in 57% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes.

Rel^E20/+ Tollo¹/+ double heterozygotes show ectopic bristles in 55% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes.

(Ayyar et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36549

Tollo¹ ry⁵⁰⁶/TM3, Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

R5A

(Ayyar et al., 2007)

Toll-8¹

(Ayyar et al., 2007, Ayyar et al., 2007)

Tollo¹

(Miller et al., 2020, Sun et al., 2017)

Tollo^R5A

(Akhouayri et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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