FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nipped-ANC106
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General Information
Symbol
Dmel\Nipped-ANC106
Species
D. melanogaster
Name
FlyBase ID
FBal0244218
Feature type
allele
Associated gene
Dmel\Nipped-A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gause et al., 2006)
Progenitor genotype
Cytology
Description

Nucleotide numbering based on a hybrid sequence with the first nucleotide of the most 5' RACE product from an isogenic cn bw chromosome defined as nucleotide 1.

(Gause et al., 2006)

Nucleotide substitution: T33610A.

(Gause et al., 2006)

Mutation affects the exon 5 splice acceptor site. The lack of splicing causes a frameshift, resulting in a truncated 265-residue protein.

(Gause et al., 2006)

Nucleotide substitution: G33613C.

(Gause et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:5,217,436..5,217,436 [-]
Nucleotide change:

G5217436C

Reported nucleotide change:

G33613C

Comment:

One of two base changes in mutant, this one in the intron 4 splice acceptor; the other is a T to A substitution three bases upstream in the intron

(Gause et al., 2006)
point_mutation
2R:5,217,439..5,217,439 [-]
Nucleotide change:

T5217439A

Reported nucleotide change:

T33610A

Comment:

One of two base changes in mutant; one is in the intron 4 splice acceptor; this one is three bases upstream in the intron.

(Gause et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 18[o]C, 3.7% of pupae from a cross of Nipped-ANC186 x Nipped-ANC106 are of the Nipped-ANC186/Nipped-ANC106 genotype.

      At 18[o]C, 14.9% of pupae from a cross of Nipped-ANC96 x Nipped-ANC106 are of the Nipped-ANC96/Nipped-ANC106 genotype.

      (Gause et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Nipped-A[+]/Nipped-ANC106 is an enhancer of wing blade phenotype of Nnd-1

      (Gause et al., 2006)

      Nipped-A[+]/Nipped-ANC106 is an enhancer of wing margin phenotype of mamg2.1

      (Gause et al., 2006)
      NOT Suppressor of
      Statement
      Reference

      Nipped-A[+]/Nipped-ANC106 is a non-suppressor of wing vein L4 phenotype of NAx-E2

      (Gause et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for Nipped-ANC106 further reduces the width of Nnd-1 wings.

      Heterozygosity for Nipped-ANC106 increases the number of wing margin nicks seen in mamg2.1 heterozygotes.

      (Gause et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This allele was originally generated in FBrf0174713.

      (Gause et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Nipped-ANC106
      (Gause et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)