FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PsnD278A.GMR
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General Information
Symbol
Dmel\PsnD278A.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0244413
Feature type
allele
Associated gene
Dmel\Psn
Associated Insertion(s)
Carried in Construct
P{GMR-Psn.D278A}
Key Links
Transgenic product class
dominant_negative_variant
(Guo et al., 2003)
missense_variant
(Guo et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Guo et al., 2003)
missense_variant
(Guo et al., 2003)
Mutagen
in vitro construct
(Guo et al., 2003)
Progenitor genotype
Carried in construct
P{GMR-Psn.D278A}
Cytology
Description

GMR regulatory sequences drive expression of a dominant negative form of Psn (which contains the D278A mutation).

(Guo et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
Psn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying PsnD278A.GMR have wild-type eyes.

      (Guo et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      PsnD278A.GMR is a suppressor of visible phenotype of Scer\GAL4GMR.APP, grimUAS.cYa

      (Guo et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      PsnD278A.GMR is a non-suppressor of visible phenotype of Scer\GAL4GMR.PF, grim::rprgr.UAS

      (Guo et al., 2003)

      PsnD278A.GMR is a non-suppressor of visible phenotype of grimGMR.PH

      (Guo et al., 2003)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      PsnD278A.GMR is a suppressor of eye phenotype of Scer\GAL4GMR.APP, grimUAS.cYa

      (Guo et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      PsnD278A.GMR is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, grim::rprgr.UAS

      (Guo et al., 2003)

      PsnD278A.GMR is a non-suppressor of eye phenotype of grimGMR.PH

      (Guo et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      PsnD278A.GMR suppresses the small eye phenotype caused by expression of grimScer\UAS.cYa under the control of Scer\GAL4GMR.T:Hsap\APP, but does not suppress the small eye phenotype caused by expression of grimGMR.PH or by expression of grim::rprgr.Scer\UAS under the control of Scer\GAL4GMR.PF.

      (Guo et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PsnD278A.GMR
      Name Synonyms
      Secondary FlyBase IDs
        References (2)