FlyBase Allele Report: Dmel\Nipped-B[NC6]

General Information

Symbol

Dmel\Nipped-B^NC6

Species

D. melanogaster

Name

FlyBase ID

FBal0244675

Feature type

allele

Associated gene

Dmel\Nipped-B

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Gause et al., 2008)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G2487T.

(Gause et al., 2008)

Amino acid replacement: G770term.

(Gause et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:4,712,652..4,712,652 [-]

Nucleotide change:

G4712652T

Reported nucleotide change:

G2487T

Amino acid change:

Reported amino acid change:

G770term

(Gause et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle (with Nipped-B⁰²⁰⁴⁷)

(Gause et al., 2008)

lethal (with Df(2R)M41A2)

(Coulthard et al., 2010)

lethal (with Nipped-B^34-3)

(Coulthard et al., 2010)

lethal (with Nipped-B^45-53)

(Coulthard et al., 2010)

lethal (with Nipped-B^292.1)

(Coulthard et al., 2010)

lethal (with Nipped-B⁴⁰⁷)

(Coulthard et al., 2010)

lethal (with Nipped-B⁰²⁰⁴⁷)

(Coulthard et al., 2010)

lethal (with Nipped-B^ch(2)54)

(Coulthard et al., 2010)

lethal (with Nipped-B^IR13)

(Coulthard et al., 2010)

lethal (with Nipped-B^k02601a)

(Coulthard et al., 2010)

lethal (with Nipped-B^L5)

(Coulthard et al., 2010)

lethal (with Nipped-B^L7)

(Coulthard et al., 2010)

lethal (with Nipped-B^La6)

(Coulthard et al., 2010)

lethal (with Nipped-B^Lf)

(Coulthard et al., 2010)

lethal (with Nipped-B^LL)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC7)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC23)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC39)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC41)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC59)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC60)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC71)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC77)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC78)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC91)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC138)

(Coulthard et al., 2010)

lethal - all die before end of second instar larval stage | recessive

(Gause et al., 2008)

some die during second instar larval stage | recessive

(Gause et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutants die at the second to third instar moult.

Neuroblast metaphase nuclei show precocious sister chromatid separation in Nipped-B⁰²⁰⁴⁷/Nipped-B^NC6 animals.

(Gause et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Nipped-B[+]/Nipped-B^NC6 is an enhancer of wing margin phenotype of ct^K

(Gause et al., 2008)

Nipped-B[+]/Nipped-B^NC6 is an enhancer of adult thorax phenotype of Ubx^bx-34e, su(Hw)^e2

(Gause et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

NC6

(Coulthard et al., 2010)

Nipped-B^NC6

(Coulthard et al., 2010, Gause et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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