FlyBase Allele Report: Dmel\su(Hw)[e2]

General Information

Symbol

Dmel\su(Hw)^e2

Species

D. melanogaster

Name

FlyBase ID

FBal0035732

Feature type

allele

Associated gene

Dmel\su(Hw)

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Dorsett, 1993, Harrison et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid substitution: in the seventh zinc finger motif of the su(Hw) protein.

(Georgiev and Kozycina, 1996)

The second Arg residue between the two His residues of zinc finger 7 is changed to His.

(Kim et al., 1996)

Mutant zinc finger.

(Morcillo et al., 1996)

Point mutation in one of the zinc fingers.

(Dorsett, 1993)

Nucleotide substitution: G2116A. Amino acid replacement: R?H. Mutation occurs at the base of the seventh zinc finger.

(Harrison et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:14,306,451..14,306,451 [-]

Nucleotide change:

G14306451A

Reported nucleotide change:

G2116A

Amino acid change:

R461H | su(Hw)-PA; R461H | su(Hw)-PB; R461H | su(Hw)-PC

Reported amino acid change:

R?H

Comment:

Reported nucleotide numbering from FBrf0048095.

(Harrison et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Mild mutation. Combination with mod(mdg4)^ul leads to a complete suppression of the mutant y^- phenotype. su(Hw)^e2/+ in combination with mod(mdg4)^ul is phenotypically similar to strong alleles such as su(Hw)^V. Partially suppresses the sc^D1 mutant phenotype. Suppression is enhanced by mod(mdg4)^ul.

(Georgiev and Kozycina, 1996)

Weak suppression of the y² phenotype.

(Harrison et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B^292.1

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴⁰⁷

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-C160.1

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-D341.1

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-D263.3

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E299.1

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E43

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E338

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has visible phenotype, enhanceable by Chi[+]/Chi^g1

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has visible phenotype, enhanceable by Chi[+]/Chi^g96.1

(Morcillo et al., 1996)

NOT Enhanced by

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-enhanceable by Nipped-A^222.3

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-enhanceable by Nipped-A³²³

(Rollins et al., 1999)

NOT suppressed by

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-suppressible by Nipped-A^222.3

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-suppressible by Nipped-A³²³

(Rollins et al., 1999)

Suppressor of

Statement

Reference

su(Hw)^e2 is a suppressor of visible phenotype of ct^L32/ct⁶

(Morcillo et al., 1996)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC6

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC7

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC23/Nipped-B[+]

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC39

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC41/Nipped-B[+]

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC59

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC71

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC77/Nipped-B[+]

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC78

(Gause et al., 2008)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^222.3

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A³²³

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-C160.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by T(2;3)Nipped-C138.2

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-A^C25/+

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-D263.3

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-D341.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E43

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E299.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E338

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^394.2

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^226.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^357.2

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A²

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B^292.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B^359.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴⁰⁷

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Chi[+]/Chi^g1

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Chi[+]/Chi^g96.1

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by wg[+]/wg^l-17

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing margin phenotype, enhanceable by wg[+]/wg^l-17

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by ap^56f/ap[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by vg[+]/vg¹

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by vg[+]/vg^dd

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g10.2/mam[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g2.1/mam[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g5.0/mam[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by sd[+]/sd^g6

(Morcillo et al., 1996)

NOT Enhanced by

Statement

Reference

ct^L32, su(Hw)^e2 has wing phenotype, non-enhanceable by RpL38^45-72

(Rollins et al., 1999)

Suppressor of

Statement

Reference

su(Hw)^e2 is a suppressor of wing phenotype of ct^L32/ct⁶

(Morcillo et al., 1996)

su(Hw)^e2 is a suppressor of phenotype of Ubx^bx-34e

(Morcillo et al., 1996, Dorsett, 1993)

su(Hw)^e2 is a suppressor of phenotype of ct⁶

(Dorsett, 1993)

Other

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype

(Gause et al., 2008)

ct⁶, su(Hw)^e2 has wing phenotype

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing margin phenotype

(Morcillo et al., 1996)

ct^83h, su(Hw)^e2 has wing phenotype

(Morcillo et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 animals display a bithorax phenotype.

(Gause et al., 2008)

ct^L32, su(Hw)^e2 double mutants display approximately 0.01 wing margin nicks per fly.

(Rollins et al., 1999)

ct⁶; su(Hw)^e2 flies have a scalloped cut wing phenotype.

(Morcillo et al., 1996)

Complete suppression of Ubx^bx-34e bithorax phenotype at 29^oC when in combination with su(Hw)⁷. Heteroallelic combinations with su(Hw)² and su(Hw)⁷ completely suppress the ct⁶ wing phenotype at 29^oC.

(Dorsett, 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Weak su(Hw) allele.

(Harrison et al., 1993)

Displays about 10% of wild type gypsy DNA binding activity.

(Morcillo et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

su(Hw)^e2

(Gause et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

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